Targeted contrast agents and activatable probes for photoacoustic imaging of cancer
Z Zhao, CB Swartchick, J Chan - Chemical Society Reviews, 2022 - pubs.rsc.org
Photoacoustic (PA) imaging has emerged as a powerful technique for the high resolution
visualization of biological processes within deep tissue. Through the development and …
visualization of biological processes within deep tissue. Through the development and …
Molecular determinants for the layering and coarsening of biological condensates: Special Issue: Emerging Investigators
Many membraneless organelles, or biological condensates, form through phase separation,
and play key roles in signal sensing and transcriptional regulation. While the functional …
and play key roles in signal sensing and transcriptional regulation. While the functional …
Dynamical control enables the formation of demixed biomolecular condensates
Cellular matter can be organized into compositionally distinct biomolecular condensates.
For example, in Ashbya gossypii, the RNA-binding protein Whi3 forms distinct condensates …
For example, in Ashbya gossypii, the RNA-binding protein Whi3 forms distinct condensates …
Linearly Interlinked Fe‐Nx‐Fe Single Atoms Catalyze High‐Rate Sodium‐Sulfur Batteries
Linearly interlinked single atoms offer unprecedented physiochemical properties, but their
synthesis for practical applications still poses significant challenges. Herein, linearly …
synthesis for practical applications still poses significant challenges. Herein, linearly …
[HTML][HTML] Multiscale modeling of genome organization with maximum entropy optimization
ABSTRACT Three-dimensional (3D) organization of the human genome plays an essential
role in all DNA-templated processes, including gene transcription, gene regulation, and …
role in all DNA-templated processes, including gene transcription, gene regulation, and …
Engineering inducible biomolecular assemblies for genome imaging and manipulation in living cells
Genome architecture and organization play critical roles in cell life. However, it remains
largely unknown how genomic loci are dynamically coordinated to regulate gene expression …
largely unknown how genomic loci are dynamically coordinated to regulate gene expression …
Nucleation of chemically active droplets
Driven chemical reactions can control the macroscopic properties of droplets, like their size.
Such active droplets are critical in structuring the interior of biological cells. Cells also need …
Such active droplets are critical in structuring the interior of biological cells. Cells also need …
HP1-driven phase separation recapitulates the thermodynamics and kinetics of heterochromatin condensate formation
MMC Tortora, LD Brennan… - Proceedings of the …, 2023 - National Acad Sciences
The spatial segregation of pericentromeric heterochromatin (PCH) into distinct, membrane-
less nuclear compartments involves the binding of Heterochromatin Protein 1 (HP1) to …
less nuclear compartments involves the binding of Heterochromatin Protein 1 (HP1) to …
Time-dependent material properties of aging biomolecular condensates from different viscoelasticity measurements in molecular dynamics simulations
AR Tejedor, R Collepardo-Guevara… - The Journal of …, 2023 - ACS Publications
Biomolecular condensates are important contributors to the internal organization of the cell
material. While initially described as liquid-like droplets, the term biomolecular condensates …
material. While initially described as liquid-like droplets, the term biomolecular condensates …
Compartmentalization with nuclear landmarks yields random, yet precise, genome organization
The 3D organization of eukaryotic genomes plays an important role in genome function.
While significant progress has been made in deciphering the folding mechanisms of …
While significant progress has been made in deciphering the folding mechanisms of …