Targeted contrast agents and activatable probes for photoacoustic imaging of cancer

Z Zhao, CB Swartchick, J Chan - Chemical Society Reviews, 2022 - pubs.rsc.org
Photoacoustic (PA) imaging has emerged as a powerful technique for the high resolution
visualization of biological processes within deep tissue. Through the development and …

Molecular determinants for the layering and coarsening of biological condensates: Special Issue: Emerging Investigators

AP Latham, B Zhang - Aggregate, 2022 - Wiley Online Library
Many membraneless organelles, or biological condensates, form through phase separation,
and play key roles in signal sensing and transcriptional regulation. While the functional …

Dynamical control enables the formation of demixed biomolecular condensates

AZ Lin, KM Ruff, F Dar, A Jalihal, MR King… - Nature …, 2023 - nature.com
Cellular matter can be organized into compositionally distinct biomolecular condensates.
For example, in Ashbya gossypii, the RNA-binding protein Whi3 forms distinct condensates …

Linearly Interlinked Fe‐Nx‐Fe Single Atoms Catalyze High‐Rate Sodium‐Sulfur Batteries

J Ruan, YJ Lei, Y Fan, MC Borras, Z Luo… - Advanced …, 2024 - Wiley Online Library
Linearly interlinked single atoms offer unprecedented physiochemical properties, but their
synthesis for practical applications still poses significant challenges. Herein, linearly …

[HTML][HTML] Multiscale modeling of genome organization with maximum entropy optimization

X Lin, Y Qi, AP Latham, B Zhang - The Journal of chemical physics, 2021 - pubs.aip.org
ABSTRACT Three-dimensional (3D) organization of the human genome plays an essential
role in all DNA-templated processes, including gene transcription, gene regulation, and …

Engineering inducible biomolecular assemblies for genome imaging and manipulation in living cells

Q Peng, Z Huang, K Sun, Y Liu, CW Yoon… - Nature …, 2022 - nature.com
Genome architecture and organization play critical roles in cell life. However, it remains
largely unknown how genomic loci are dynamically coordinated to regulate gene expression …

Nucleation of chemically active droplets

N Ziethen, J Kirschbaum, D Zwicker - Physical Review Letters, 2023 - APS
Driven chemical reactions can control the macroscopic properties of droplets, like their size.
Such active droplets are critical in structuring the interior of biological cells. Cells also need …

HP1-driven phase separation recapitulates the thermodynamics and kinetics of heterochromatin condensate formation

MMC Tortora, LD Brennan… - Proceedings of the …, 2023 - National Acad Sciences
The spatial segregation of pericentromeric heterochromatin (PCH) into distinct, membrane-
less nuclear compartments involves the binding of Heterochromatin Protein 1 (HP1) to …

Time-dependent material properties of aging biomolecular condensates from different viscoelasticity measurements in molecular dynamics simulations

AR Tejedor, R Collepardo-Guevara… - The Journal of …, 2023 - ACS Publications
Biomolecular condensates are important contributors to the internal organization of the cell
material. While initially described as liquid-like droplets, the term biomolecular condensates …

Compartmentalization with nuclear landmarks yields random, yet precise, genome organization

K Kamat, Z Lao, Y Qi, Y Wang, J Ma, B Zhang - Biophysical Journal, 2023 - cell.com
The 3D organization of eukaryotic genomes plays an important role in genome function.
While significant progress has been made in deciphering the folding mechanisms of …