Purpose of review In this review, we emphasize up-to-date practical cytogenetic and
molecular aspects of chronic myeloid leukemia (CML) and summarize current knowledge on …

P53 is renowned as a cellular tumor suppressor poised to instigate remedial responses to
various stress insults that threaten DNA integrity. P53 levels and activities are kept under …

The expression of the suppressor of cytokine signalling‐1 (SOCS1) protein is induced in
response to stimulation by several cytokines. The induced SOCS1 inhibits the signalling …

Reciprocal chromosomal translocations may arise as a result of unfaithful repair of
spontaneous DNA double-strand breaks, most probably induced by oxidative stress …

Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder, characterized by
the presence of BCR/ABL fusion gene. It is unclear which cellular events drive BCR/ABL …

Tumor dormancy, a complex and still poorly understood phenomenon observed both in
experimental models and in patients, has been associated with insufficient angiogenic …

Purpose: The present study analyzed treatment outcomes of imatinib therapy by
interindividual genetic variants in candidate biological pathways of chronic myeloid …

Gene fusions are common driver events in leukaemias and solid tumours; here we present
FusionAnalyser, a tool dedicated to the identification of driver fusion rearrangements in …

The well‐established molecular pathogenesis of chronic myelogenous leukemia (CML) and
its consequences for laboratory testing and clinical management illustrate a classic …

Although the leading dogma for the origin of the diversity in cancer cell subpopulations is
based on a stepwise selection and accumulation of genetic changes that allow …