Receptor-mediated signaling plays an important role in health and disease. Recent reports
have revealed that many proteins that do not adopt globular structures under native …

Triggering receptor expressed on myeloid cells-1 (TREM-1) amplifies the inflammatory
response and plays a role in cancer and sepsis. Inhibition of TREM-1 by short hairpin RNA …

The emergence of intrinsically disordered proteins (IDPs) has challenged the classical
protein structure-function paradigm by introducing a new paradigm of “coupled binding and …

Pancreatic cancer (PC) is a highly lethal cancer with an urgent need to expand the limited
treatment options for patients. Tumor-associated macrophages (TAMs) promote tumor …

Triggering receptor expressed on myeloid cells 1 (TREM‐1) is critically involved in the
pathogenesis of rheumatoid arthritis (RA). In contrast to cytokine blockers, therapeutic …

Viruses have evolved several strategies to modify cellular processes and evade the immune
response in order to successfully infect, replicate, and persist in the host. By utilizing in-silico …

During the co-evolution of viruses and their hosts, the viruses have evolved numerous
strategies to counter and evade host antiviral immune responses in order to establish a …

During co-evolution with their hosts, many viruses have evolved a membrane fusion
mechanism to facilitate host cell entry. Examples are human immunodeficiency virus type 1 …

Receptor-mediated transmembrane signaling plays an important role in health and disease.
Recent significant advances in our understanding of the molecular mechanisms linking …

Highlights•SCHOOL model reveals the protein-protein interactions in transmembrane
signaling.•Intramembrane protein-protein interactions involved in signaling are …