Bioluminescence (BL) is a spectacular phenomenon involving light emission by live
organisms. It is caused by the oxidation of a small organic molecule, luciferin, with molecular …

Alveolarization is the process by which the alveoli, the principal gas exchange units of the
lung, are formed. Along with the maturation of the pulmonary vasculature, alveolarization is …

Numerous compounds have shown efficacy in limiting development of pulmonary fibrosis
using animal models, yet few of these compounds have replicated these beneficial effects in …

In utero, fetal lung epithelial cells actively secrete Cl− ions into the lung air spaces while Na+
ions follow passively to maintain electroneutrality. This process, driven by an …

Although increasing used in the preclinical testing of new anti-fibrotic drugs, a thorough
validation of micro-computed tomography (CT) in pulmonary fibrosis models has not been …

Experimental models are critical for the understanding of lung health and disease and are
indispensable for drug development. However, the pathogenetic and clinical relevance of …

In vivo lung micro-computed tomography (micro-CT) is being increasingly embraced in
pulmonary research because it provides longitudinal information on dynamic disease …

The development of clinically acceptable albumin-based nanoparticle formulations for use in
pulmonary drug delivery has been hindered by concerns about the toxicity of nanomaterials …

Current literature on pulmonary fibrosis induced in animal models highlights the need of an
accurate, reliable and reproducible histological quantitative analysis. One of the major limits …

Pulmonary formulations have been attracting much attention because of their direct effects
on respiratory diseases, but also their non-invasive administration for the treatment of …