In the tissue engineering (TE) paradigm, engineering and life sciences tools are combined
to develop bioartificial substitutes for organs and tissues, which can in turn be applied in …

Although cellular therapies hold great promise for the treatment of human disease, results
from several initial clinical trials have not shown a level of efficacy required for their use as a …

A major research focus in the field of cardiovascular medicine is the prospect of using stem
cells and progenitor cells for cardiac regeneration. With the advent of induced pluripotent …

Rationale: Cardiac myocytes derived from pluripotent stem cells have demonstrated the
potential to mitigate damage of the infarcted myocardium and improve left ventricular …

Cardiovascular disease is the leading cause of death worldwide. Achieving the next phase
of potential treatment strategies and better prognostic tools will require a concerted effort …

The four platelet-derived growth factor (PDGF) ligands and PDGF receptors (PDGFRs), α
and β (PDGFRA, PDGFRB), are essential proteins that are expressed during embryonic and …

Background: Human induced pluripotent stem cells (iPSCs) play an important role in
disease modeling and drug testing. However, the current methods are time-consuming and …

Imaging reporter genes provides longitudinal information on the biodistribution, growth, and
survival of engineered cells in vivo. A translational bottleneck to using reporter genes is the …

Tools for rapid and efficient transgenesis in" safe harbor" loci in an isogenic context remain
important to exploit the possibilities of human pluripotent stem cells (hPSCs). We created …

The emergence of induced pluripotent stem cell (iPSC) technology paves the way to
generate large numbers of patient-specific endothelial cells (ECs) that can be potentially …