IL-7: comprehensive review
Overview IL-7 is a member of the family of cytokines with four anti-parallel α helixes that bind
Type I cytokine receptors. It is produced by stromal cells and is required for development …
Type I cytokine receptors. It is produced by stromal cells and is required for development …
The m6A RNA methylation regulates oncogenic signaling pathways driving cell malignant transformation and carcinogenesis
The m 6 A RNA methylation is the most prevalent internal modification in mammalian
mRNAs which plays critical biological roles by regulating vital cellular processes …
mRNAs which plays critical biological roles by regulating vital cellular processes …
Paradigm shift of “classical” HDAC inhibitors to “hybrid” HDAC inhibitors in therapeutic interventions
GN Vaidya, P Rana, A Venkatesh… - European journal of …, 2021 - Elsevier
Abstract 'Epigenetic'regulation of genes via post-translational modulation of proteins is the
current mainstay approach for the disease therapies, particularly explored in the Histone …
current mainstay approach for the disease therapies, particularly explored in the Histone …
Progress on the pharmacological targeting of Janus pseudokinases
SP Henry, WL Jorgensen - Journal of Medicinal Chemistry, 2023 - ACS Publications
The Janus kinases (JAKs) are key components of the JAK-STAT signaling pathway and are
involved in myriad physiological processes. Though they are the molecular targets of many …
involved in myriad physiological processes. Though they are the molecular targets of many …
8-Hydroxydaidzein, an isoflavone from fermented soybean, induces autophagy, apoptosis, differentiation, and degradation of oncoprotein BCR-ABL in K562 Cells
8-Hydroxydaidzein (8-OHD, 7, 8, 4′-trihydoxyisoflavone) is a hydroxylated derivative of
daidzein isolated from fermented soybean products. The aim of this study is to investigate …
daidzein isolated from fermented soybean products. The aim of this study is to investigate …
Enhanced Hsa-miR-181d/p-STAT3 and Hsa-miR-181d/p-STAT5A Ratios Mediate the Anticancer Effect of Garcinol in STAT3/5A-Addicted Glioblastoma
HW Liu, PM Lee, OA Bamodu, YK Su, IH Fong, CT Yeh… - Cancers, 2019 - mdpi.com
Background: Glioblastoma (GBM), a malignant grade IV tumor, is the most malignant brain
tumor due to its hyper-proliferative and apoptosis-evading characteristics. The signal …
tumor due to its hyper-proliferative and apoptosis-evading characteristics. The signal …
Exploring dysregulated signaling pathways in cancer
Cancer cell biology takes advantage of identifying diverse cellular signaling pathways that
are disrupted in cancer. Signaling pathways are an important means of communication from …
are disrupted in cancer. Signaling pathways are an important means of communication from …
8-Hydroxydaidzein downregulates JAK/STAT, MMP, oxidative phosphorylation, and PI3K/AKT pathways in K562 cells
A metabolite isolated from fermented soybean, 8-hydroxydaidzein (8-OHD, 7, 8, 4′-
trihydroxyisoflavone, NSC-678112), is widely used in ethnopharmacological research due to …
trihydroxyisoflavone, NSC-678112), is widely used in ethnopharmacological research due to …
Discovery of furopyridine-based compounds as novel inhibitors of Janus kinase 2: In silico and in vitro studies
U Suriya, P Mahalapbutr, A Geronikaki… - International Journal of …, 2024 - Elsevier
Abstract Janus kinase 2 (JAK2), one of the JAK isoforms participating in a JAK/STAT
signaling cascade, has been considered a potential clinical target owing to its critical role in …
signaling cascade, has been considered a potential clinical target owing to its critical role in …
Elucidating the role of long intergenic non-coding RNA 339 in human endometrium and endometriosis
SJ Holdsworth-Carson, M Churchill… - Molecular Human …, 2021 - academic.oup.com
Endometriosis is a complex disease, influenced by genetic factors. Genetic markers
associated with endometriosis exist at chromosome 1p36. 12 and lead to altered expression …
associated with endometriosis exist at chromosome 1p36. 12 and lead to altered expression …