Abstract mRNA vaccines have emerged as highly effective strategies in the prophylaxis and
treatment of diseases, thanks largely although not totally to their extraordinary performance …

In recent years, cancer immunotherapy has emerged as an exciting cancer treatment.
Immune checkpoint blockade brings new opportunities for more researchers and clinicians …

Chemotherapy is crucial in oncology for combating malignant tumors but often encounters
obatacles such as severe adverse effects, drug resistance, and biocompatibility issues. The …

Biopolymers with excellent biocompatibility and biodegradability show great potential for
designing drug nanocarriers, while it's difficult to fabricate smart vehicles with multiple …

Background Breast cancer has become the most common cancer in women. Compare with
other subtypes of breast cancer, triple-negative breast cancer (TNBC) is more likely to …

A computational method was proposed in this work for prediction of drug solubility in
supercritical solvent for the drug desoxycorticosterone acetate as a case study. The main …

Immune checkpoint blockade (ICB) has achieved unprecedented progress in tumor
immunotherapy by blocking specific immune checkpoint molecules. However, the high …

FMS-like tyrosine kinase 3 (FLT3) is a viable and important therapeutic target for acute
myeloid leukemia (AML). FLT3 internal tandem duplication (FLT3-ITD) mutations have been …

The therapy of life-threatening fungal infections is limited and needs urgent improvement.
This is in part due to toxic side effects of clinically used antifungal compounds or their limited …

Non‐viral vector chimeric antigen receptor (CAR)‐T cells have garnered increasing attention
due to their ability to efficiently eradicate cancer cells while mitigating undesirable side …