A crucial component in regulating cardiac and skeletal muscles contractility is the release of
Ca2+ via ryanodine receptor (RyR) Ca2+ release channels in the sarcoplasmic reticulum …

In cardiac muscle, a number of posttranslational protein modifications can alter the function
of the Ca2+ release channel of the sarcoplasmic reticulum (SR), also known as the …

Abstract Calcium (Ca 2+) release from intracellular stores plays a key role in the regulation
of skeletal muscle contraction. The type 1 ryanodine receptors (RyR1) is the major Ca 2+ …

Mutations in WFS1 (which encodes Wolframin, WFS1) and CISD2 (which encodes CDGSH
iron sulfur domain 2) result in Wolfram syndrome (WS), a rare genetic disorder that starts …

Cardiovascular diseases, such as stroke and myocardial infarction (MI) remain the major
cause of death and disability worldwide. However, the mortality of MI has declined …

Duchenne muscular dystrophy (DMD) is caused by mutations in the dystrophin gene and
dilated cardiomyopathy (DCM) is a major cause of morbidity and mortality in DMD patients …

The Dystrophin-Associated Protein Complex (DAPC) is a well-defined and evolutionarily
conserved complex in animals. DAPC interacts with the F-actin cytoskeleton via dystrophin …

Background Disruption of the sarcolemma-associated dystrophin-glycoprotein complex
underlies multiple forms of muscular dystrophy, including Duchenne muscular dystrophy …

Ventricular arrhythmogenesis is a key cause of sudden cardiac death following myocardial
infarction (MI). Accumulating data show that ischemia, sympathetic activation, and …

Background Dantrolene binds to the Leu 601-Cys 620 region of the N-terminal domain of
cardiac ryanodine receptor (RyR2), which corresponds to the Leu 590-Cys 609 region of the …