Calcific aortic valve disease (CAVD) is the most common disorder affecting heart valves and
is characterized by thickening, fibrosis and mineralization of the aortic valve leaflets …

Calcific aortic valve disease is dramatically increasing in global burden, yet no therapy
exists outside of prosthetic replacement. The increasing proportion of younger and more …

Calcific aortic valve disease (CAVD) is a common acquired valvulopathy, which carries a
high burden of mortality. Chronic inflammation has been postulated as the predominant …

Despite the focus placed on cardiovascular research, the prevalence of vascular and
valvular calcification is increasing and remains a leading contributor of cardiovascular …

BACKGROUND: Cardiac valve disease is observed in 2.5% of the general population and
10% of the elderly people. Effective pharmacological treatments are currently not available …

Aortic valve stenosis secondary to aortic valve calcification is the most common valve
disease in the Western world. Calcification is a result of pathological proliferation and …

Although the underlying mechanisms driving human immunodeficiency virus (HIV)-mediated
cardiovascular diseases (CVD) onset and progression remain unclear, the role of chronic …

Aortic stenosis (AS) is the most common heart valve disease requiring surgery in developed
countries, with a rising global burden associated with aging populations. The predominant …

There are currently no pharmacological therapies for calcific aortic valve disease (CAVD).
Here, we evaluated the role of protein tyrosine phosphatase 1B (PTP1B) inhibition in CAVD …

Cardiovascular mechanical stresses trigger physiological and pathological cellular reactions
including secretion of Transforming Growth Factor β1 ubiquitously in a latent form (LTGF …