In recent years, accumulating evidence has elucidated the role of lysosomes in dynamically
regulating cellular and organismal homeostasis. Lysosomal changes and dysfunction have …

The occurrence of nonalcoholic fatty liver disease (NAFLD) is associated with major
abnormalities of hepatic lipid metabolism. We propose that lipid abnormalities directly or …

The prevalence of nonalcoholic steatohepatitis (NASH) is increasing worldwide, yet there
are no effective treatments. A decade has passed since the initial lipidomics analyses of liver …

Non-alcoholic fatty liver disease—the most common chronic liver disease—encompasses a
histological spectrum ranging from simple steatosis to non-alcoholic steatohepatitis (NASH) …

Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease affecting up to 30% of the
general adult population. NAFLD encompasses a histological spectrum ranging from pure …

With the advent of nanotechnology, various modes of traditional treatment strategies have
been transformed extensively owing to the advantageous morphological, physiochemical …

Lysosomes are organelles responsible for the breakdown and recycling of cellular
machinery. Dysfunctional lysosomes give rise to lysosomal storage disorders as well as …

This literature review investigates the significant overlap between myelin-repair signaling
pathways and pathways known to contribute to hallmark pathologies of Alzheimer's disease …

The abnormal accumulation of lipids within the endolysosomal lumen occurs in many
conditions, including lysosomal storage disorders, atherosclerosis, nonalcoholic fatty liver …

During cell entry, non-enveloped viruses undergo partial uncoating to expose membrane
lytic proteins for gaining access to the cytoplasm. We report that adenovirus uses membrane …