Targeting PI3K/Akt signaling in prostate cancer therapy

M Hashemi, A Taheriazam, P Daneii… - Journal of Cell …, 2023 - Springer
Urological cancers have obtained much attention in recent years due to their mortality and
morbidity. The most common and malignant tumor of urological cancers is prostate cancer …

Biological functions and molecular interactions of Wnt/β-catenin in breast cancer: Revisiting signaling networks

M Hashemi, S Hasani, S Hajimazdarany… - International Journal of …, 2023 - Elsevier
Abstract Changes in lifestyle such as physical activity and eating habits have been one of
the main reasons for development of various diseases in modern world, especially cancer …

Metabolomics and integrated network pharmacology analysis reveal SNKAF decoction suppresses cell proliferation and induced cell apoptisis in hepatocellular …

W Guo, X Yao, S Lan, C Zhang, H Li, Z Chen, L Yu… - Chinese Medicine, 2022 - Springer
Background There is no comprehensive treatment method for hepatocellular carcinoma
(HCC); hence, research and development are still focused on systemic therapies, including …

Proteomic Profiling of Extracellular Vesicles Isolated from Plasma and Peritoneal Exudate in Mice Induced by Crotalus scutulatus scutulatus Crude Venom and Its …

A Reyes, JD Hatcher, E Salazar, J Galan, A Iliuk… - Toxins, 2023 - mdpi.com
Increased vascular permeability is a frequent outcome of viperid snakebite envenomation,
leading to local and systemic complications. We reported that snake venom cysteine-rich …

Gallic acid suppresses the progression of triple-negative breast cancer HCC1806 cells via modulating PI3K/AKT/EGFR and MAPK signaling pathways

S Lin, HZ Qin, ZY Li, H Zhu, L Long… - Frontiers in Pharmacology, 2022 - frontiersin.org
Triple-negative breast cancer (TNBC) is a severe threat to women's health because of its
aggressive nature, early age of onset, and high recurrence rate. Therefore, in this study, we …

Inorganic pyrophosphatase 1 activates the phosphatidylinositol 3-kinase/Akt signaling to promote tumorigenicity and stemness properties in colorectal cancer

T Niu, J Zhu, L Dong, P Yuan, L Zhang, D Liu - Cellular Signalling, 2023 - Elsevier
Colorectal cancer (CRC) is a common malignant tumor of the human digestive tract.
Inorganic pyrophosphatase 1 (PPA1) plays an imperative role in the advancement of …

[HTML][HTML] Identification and verification of an exosome-related gene risk model to predict prognosis and evaluate immune infiltration for colorectal cancer

H Shao, L Yao, Y Tao, X Huang - Medicine, 2023 - journals.lww.com
Colorectal cancer (CRC) is a common malignant tumor that severely endangers human
health. Exosomes show great potential in tumor immunotherapy. Increasingly studies have …

PTGER3 knockdown inhibits the vulnerability of triple‐negative breast cancer to ferroptosis

S Wang, Y Zhang, D Zhang, J Meng, N Che… - Cancer …, 2024 - Wiley Online Library
Abstract Prostaglandin E receptor 3 (PTGER3) is involved in a variety of biological
processes in the human body and is closely associated with the development and …

[HTML][HTML] PPA1, an energy metabolism initiator, plays an important role in the progression of malignant tumors

S Wang, J Wei, S Li, Y Luo, Y Li, X Wang… - Frontiers in …, 2022 - frontiersin.org
Inorganic pyrophosphatase (PPA1) encoded by PPA1 gene belongs to Soluble
Pyrophosphatases (PPase) family and is expressed widely in various tissues of Homo …

Proteome derangement in malignant epithelial cells and its stroma following exposure to 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone

K Marshall, Y Twum, W Gao - Archives of toxicology, 2023 - Springer
Discovering novel changes in the proteome of malignant lung epithelial cells and/or the
tumor-microenvironment is paramount for diagnostic, prognostic, and/or therapy …