Non-viral gene delivery vectors have lagged far behind viral ones in the current pipeline of
clinical trials of gene therapy nanomedicines. Even when non-viral nanovectors pose less …

Chronic rhinosinusitis (CRS) is highly prevalent in patients with cystic fibrosis (CF) and
accounts for significant morbidity and contribution to CF lung disease. Mutations of the cystic …

The mechanisms underlying the development and natural progression of the airway mucus
defect in cystic fibrosis (CF) remain largely unclear. New animal models of CF, coupled with …

Antibiotic resistance is a serious health and social problem that will have a substantial
impact in the coming years on the world health and economy. Thus, the increasing demand …

Tonicity of saline (NaCl) is important in regulating cellular functions and homeostasis.
Hypertonic saline is administered to treat many inflammatory diseases, including cystic …

Cystic fibrosis (CF) intestinal disease is associated with the pathological manifestation
mucoviscidosis, which is the secretion of tenacious, viscid mucus that plugs ducts and …

Cystic fibrosis (CF) is a multiorgan, genetic disease resulting from dysfunction of the CF
transmembrane conductance regulator. The primary clinical manifestations are …

Various pathophysiological conditions such as surfactant dysfunction, mechanical
ventilation, inflammation, pathogen products, environmental exposures, and gastric acid …

Cystic fibrosis (CF) occurs when the cystic fibrosis transmembrane conductance regulator
(CFTR) protein is not synthetized and folded correctly. The CFTR protein helps to maintain …

Salt provides 2 life-essential elements: sodium and chlorine. Chloride, the ionic form of
chlorine, derived exclusively from dietary absorption and constituting the most abundant …