Albuminuria is the hallmark of both primary and secondary proteinuric glomerulopathies,
including focal segmental glomerulosclerosis (FSGS), obesity-related nephropathy, and …

Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and end-
stage renal disease. The natural history of DKD includes glomerular hyperfiltration …

How cells become specialized, or" mature," is important for cell and developmental biology.
While maturity is usually deemed a terminal fate, it may be more helpful to consider …

Podocytes are an integral part of the glomerular filtration barrier, a structure that prevents
filtration of large proteins and macromolecules into the urine. Podocyte function is …

Diabetic nephropathy (DN) is a serious kidney-related complication of both type 1 and type 2
diabetes mellitus (T1DM, T2DM) and the second major cause of end-stage kidney disease …

Expansion microscopy physically enlarges biological specimens to achieve nanoscale
resolution using diffraction-limited microscopy systems. However, optimal performance is …

High-mobility group protein box 1 (HMGB1) is a member of a highly conserved high-mobility
group protein present in all cell types. HMGB1 plays multiple roles both inside and outside …

The use of biomimetic models of the glomerulus has the potential to improve our
understanding of the pathogenesis of kidney diseases and to enable progress in …

Recent advances in single-cell sequencing provide a unique opportunity to gain novel
insights into the diversity, lineage, and functions of cell types constituting a tissue/organ …

Alport syndrome is a hereditary disorder characterized by kidney disease, ocular
abnormalities, and sensorineural hearing loss. Work in understanding the cause of Alport …