The emerging roles of TRIM21 in coordinating cancer metabolism, immunity and cancer treatment
X Chen, M Cao, P Wang, S Chu, M Li, P Hou… - Frontiers in …, 2022 - frontiersin.org
Tripartite motif containing-21 (TRIM21), an E3 ubiquitin ligase, was initially found to be
involved in antiviral responses and autoimmune diseases. Recently studies have reported …
involved in antiviral responses and autoimmune diseases. Recently studies have reported …
Significance of RB loss in unlocking phenotypic plasticity in advanced cancers
VB Venkadakrishnan, Y Yamada, K Weng… - Molecular Cancer …, 2023 - AACR
Cancer cells can undergo plasticity in response to environmental stimuli or under selective
therapeutic pressures that result in changes in phenotype. This complex phenomenon of …
therapeutic pressures that result in changes in phenotype. This complex phenomenon of …
Development of pyrolo [2, 3-c] pyrazole, pyrolo [2, 3-d] pyrimidine and their bioisosteres as novel CDK2 inhibitors with potent in vitro apoptotic anti-proliferative activity …
Inhibiting the CDK2/cyclin A2 enzyme has been validated in multiple clinical manifestations
related to multiple types of cancer. Herein, novel series of pyrolo [2, 3-c] pyrazole, pyrolo [2 …
related to multiple types of cancer. Herein, novel series of pyrolo [2, 3-c] pyrazole, pyrolo [2 …
Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding
Compared to most ATP-site kinase inhibitors, small molecules that target an allosteric pocket
have the potential for improved selectivity due to the often observed lower structural …
have the potential for improved selectivity due to the often observed lower structural …
Machine Learning-Based Virtual Screening and Molecular Simulation Approaches Identified Novel Potential Inhibitors for Cancer Therapy
Cyclin-dependent kinase 2 (CDK2) is a promising target for cancer treatment, developing
new effective CDK2 inhibitors is of great significance in anticancer therapy. The involvement …
new effective CDK2 inhibitors is of great significance in anticancer therapy. The involvement …
DNMT1-targeting remodeling global DNA hypomethylation for enhanced tumor suppression and circumvented toxicity in oral squamous cell carcinoma
Y Liu, Y Sun, J Yang, D Wu, S Yu, J Liu, T Hu, J Luo… - Molecular Cancer, 2024 - Springer
Background The faithful maintenance of DNA methylation homeostasis indispensably
requires DNA methyltransferase 1 (DNMT1) in cancer progression. We previously identified …
requires DNA methyltransferase 1 (DNMT1) in cancer progression. We previously identified …
Screening through lead optimization of high affinity, allosteric cyclin-dependent kinase 2 (CDK2) inhibitors as male contraceptives that reduce sperm counts in mice
Although cyclin-dependent kinase 2 (CDK2) is a validated target for both cancer and
contraception, developing a CDK2 inhibitor with exquisite selectivity has been challenging …
contraception, developing a CDK2 inhibitor with exquisite selectivity has been challenging …
TRIM21‐promoted FSP1 plasma membrane translocation confers ferroptosis resistance in human cancers
J Gong, Y Liu, W Wang, R He, Q Xia, L Chen… - Advanced …, 2023 - Wiley Online Library
Ferroptosis, an iron‐dependent form of regulated cell death driven by excessive
accumulation of lipid peroxides, has become a promising strategy in cancer treatment …
accumulation of lipid peroxides, has become a promising strategy in cancer treatment …
Identification of core therapeutic targets for Monkeypox virus and repurposing potential of drugs against them: An in silico approach
Monkeypox virus (mpox virus) outbreak has rapidly spread to 82 non-endemic countries.
Although it primarily causes skin lesions, secondary complications and high mortality (1 …
Although it primarily causes skin lesions, secondary complications and high mortality (1 …
Characteristics of anticancer activity of CBP/p300 inhibitors–Features of their classes, intracellular targets and future perspectives of their application in cancer …
M Strachowska, A Robaszkiewicz - Pharmacology & Therapeutics, 2024 - Elsevier
Due to the contribution of highly homologous acetyltransferases CBP and p300 to
transcription elevation of oncogenes and other cancer promoting factors, these enzymes …
transcription elevation of oncogenes and other cancer promoting factors, these enzymes …