Remote ischemic preconditioning reduces myocardial ischemia–reperfusion injury through unacylated ghrelin-induced activation of the JAK/STAT pathway

Y Sawashita, N Hirata, Y Yoshikawa, H Terada… - Basic Research in …, 2020 - Springer
Remote ischemic preconditioning (RIPC) offers cardioprotection against myocardial
ischemia–reperfusion injury. The humoral factors involved in RIPC that are released from …

Dexmedetomidine maintains its direct cardioprotective effect against ischemia/reperfusion injury in hypertensive hypertrophied myocardium

Y Yoshikawa, N Hirata, R Kawaguchi… - Anesthesia & …, 2018 - journals.lww.com
BACKGROUND: Dexmedetomidine (DEX) has a direct cardioprotective effect against
ischemia/reperfusion injury through endothelial nitric oxide synthase (eNOS) …

[PDF][PDF] Renin-angiotensin blockade is associated with increased mortality after vascular surgery

CJ Railton, J Wolpin, J Lam-McCulloch… - Canadian Journal of …, 2010 - researchgate.net
Conclusions Examination of 883 cases of AAA repair showed increased mortality associated
with preoperative RAS blockade. A better understanding of perioperative pharmacology and …

Effects of anesthetic agents on contractions of the pregnant rat myometrium in vivo and in vitro

M Kimizuka, Y Tokinaga, R Azumaguchi, K Hamada… - Journal of …, 2021 - Springer
Background Several anesthetic agents are used in cesarean sections for both regional and
general anesthesia purposes. However, there are no data comparing the in vivo effects of …

Apocynum venetum leaf extract, an antihypertensive herb, inhibits rat aortic contraction induced by angiotensin II: a nitric oxide and superoxide connection

YS Lau, CY Kwan, TC Ku, WT Hsieh, HD Wang… - Journal of …, 2012 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: The leaves extract of Apocynum venetum
(AVLE), also known as “luobuma”, have long been used in traditional Chinese medicine to …

Gynura procumbens causes vasodilation by inhibiting angiotensin II and enhancing bradykinin actions

TF Poh, HK Ng, SZ Hoe, SK Lam - Journal of cardiovascular …, 2013 - journals.lww.com
Previous studies showed that Gynura procumbens reduced blood pressure by blocking
calcium channels and inhibiting the angiotensin-converting enzyme activity. The present …

Central Artery Hemodynamics in Angiotensin II-Induced Hypertension and Effects of Anesthesia

SE Hopper, D Weiss, N Mikush, B Jiang… - Annals of Biomedical …, 2024 - Springer
Systemic hypertension is a strong risk factor for cardiovascular, neurovascular, and
renovascular diseases. Central artery stiffness is both an initiator and indicator of …

Volatile anesthetics inhibit angiotensin II-induced vascular contraction by modulating myosin light chain phosphatase inhibiting protein, CPI-17 and regulatory subunit …

F Qi, K Ogawa, Y Tokinaga, N Uematsu… - Anesthesia & …, 2009 - journals.lww.com
BACKGROUND: Vascular contraction is regulated by myosin light chain (MLC)
phosphorylation. Inhibition of MLC phosphatase (MLCP) increases MLC phosphorylation for …

Hemodynamic effects of incremental doses of acepromazine in isoflurane-anesthetized dogs

JPP Rangel, ER Monteiro, FS Bitti, JSN Junior… - Veterinary anaesthesia …, 2021 - Elsevier
Objective To evaluate the effects of incremental doses of acepromazine on hemodynamics
in isoflurane-anesthetized dogs. Study design Prospective, experimental study. Animals …

Desflurane inhibits endothelium-dependent vasodilation more than sevoflurane with inhibition of endothelial nitric oxide synthase by different mechanisms

S Kazuma, Y Tokinaga, Y Takada… - Biochemical and …, 2018 - Elsevier
The effects of desflurane on endothelium-dependent vasodilation remain uncertain,
whereas sevoflurane is known to inhibit it. Endothelium-dependent vasodilation is mainly …