Abstract 'Reactive oxygen species'(ROS) is a generic term that defines a wide variety of
oxidant molecules with vastly different properties and biological functions that range from …

More and more in-depth studies have revealed that the occurrence and development of
tumors depend on gene mutation and tumor heterogeneity. The most important …

Lung cancer is a common malignant tumor that occurs in the human body and poses a
serious threat to human health and quality of life. The existing treatment methods mainly …

Significance: Thioredoxin (Trx) is a powerful antioxidant that reduces protein disulfides to
maintain redox stability in cells and is involved in regulating multiple redox-dependent …

Drug resistance is one of the biggest challenges in cancer treatment and limits the potential
to cure patients. In many tumors, sustained activation of the protein NRF2 makes tumor cells …

Cancer is one of the most fatal diseases with an increasing incidence and mortality all over
the world. Thus, there is an urgent need for novel therapies targeting major cancer-related …

Significance: The mitochondrial oxidative phosphorylation (OXPHOS) system, comprising
the electron transport chain and ATP synthase, generates membrane potential, drives ATP …

Abstract Purpose: Cisplatin (CDDP)-based chemotherapy is a first-line treatment for patients
with advanced head and neck squamous cell carcinomas (HNSCC), despite a high rate of …

Reactive oxygen species play a major role in the induction of programmed cell death and
numerous diseases. Production of reactive oxygen species is ubiquitous in biological …

Abstract Background Multidrug-resistant Gram-negative bacteria are the most pressing
problem in treating infectious diseases. As one of the primary drugs for multidrug-resistant …