Diabetes mellitus is a pandemic metabolic disorder that results from either the autoimmune
destruction or the dysfunction of insulin-producing pancreatic beta cells. A promising cure is …

This review describes formation of the islet basement membrane and the function of
extracellular matrix (ECM) components in β-cell proliferation and survival. Implications for …

A sedentary lifestyle is associated with overweight/obesity, which involves excessive fat
body accumulation, triggering structural and functional changes in tissues, organs, and body …

A major hindrance in islet transplantation as a feasible therapeutic approach for patients
with type 1 diabetes is the insufficient oxygenation of the grafts, which results in cell death in …

Reciprocal signalling between the endothelium and the pancreatic epithelium is crucial for
coordinated differentiation of the embryonic endocrine and exocrine pancreas. In the adult …

A comparative analysis of mouse and human pancreatic development may reveal common
mechanisms that control key steps as organ morphogenesis and cell proliferation and …

Islet transplantation has been hampered by loss of function due to poor revascularization.
We hypothesize that co-transplantation of islets with human embryonic stem cell-derived …

In the pathogenesis of diabetes mellitus (DM), islet microvasculares are severely damaged
due to glucolipotoxicity and other reasons. Vascular endothelial growth factor (VEGF) is an …

Aims/hypothesis The initial avascular period following islet transplantation seriously
compromises graft function and survival. Enhancing graft revascularisation to improve …

Methyl mercury is an environmental contaminant of worldwide concern. Since the discovery
of methyl mercury exposure due to eating contaminated fish as the underlying cause of the …