Dyslipidaemia has a prominent role in the onset of notorious atherosclerosis, a disease of
medium to large arteries. Atherosclerosis is the prime root of cardiovascular events …

Simple Summary The progressive nature of type 2 diabetes mellitus (T2DM) leads to micro-
and macro-vascular complications, including renal and cardiovascular disease. These …

Significance: Atherosclerotic cardiovascular diseases (ACVDs) continue to be a primary
cause of mortality worldwide in adults aged 35–70 years, occurring more often in countries …

910 levels, whereas PCSK9 overexpression did not cause an increase in plasma lipids but
in atherosclerotic lesion size18, 19). The Atheroma IVUS study revealed that the necrotic …

Atherosclerosis is the primary cause of several cardiovascular diseases. Oxidized low-
density lipoprotein (ox-LDL)-induced apoptosis, endothelial–mesenchymal transition …

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is the last discovered member of the
family of proprotein convertases (PCs), mainly synthetized in hepatic cells. This serine …

The oxygenation of polyunsaturated fatty acids such as arachidonic and linoleic acid
through lipoxygenases (LOX s) and cyclooxygenases (COX s) leads to the production of …

Atherosclerosis is a chronic disease which involves the build up of cholesterol and fatty
deposits within the inner lining of the artery. It is associated with a progressive thickening …

Liver is a metabolically complex organ that influences nutrient partitioning and potentially
modulates the efficiency of converting energy acquired from macronutrients ingestion into a …

Background: The exact mechanism (s) of atherosclerosis in humans remains elusive, but
one theory hypothesizes that this deleterious process results from the oxidative modification …