The role of IL-6 in cancer cell invasiveness and metastasis—overview and therapeutic opportunities

M Rašková, L Lacina, Z Kejík, A Venhauerová… - Cells, 2022 - mdpi.com
Interleukin 6 (IL-6) belongs to a broad class of cytokines involved in the regulation of various
homeostatic and pathological processes. These activities range from regulating embryonic …

Ivermectin: a controversial focal point during the COVID-19 pandemic

M Castillejos-López, LM Torres-Espíndola… - Life, 2022 - mdpi.com
The SARS-CoV-2 pandemic has confirmed the apocalyptic predictions that virologists have
been making for several decades. The challenge the world is facing is that of trying to find a …

Theophylline Attenuates BLM-Induced Pulmonary Fibrosis by Inhibiting Th17 Differentiation

SJ Park, HJ Hahn, SR Oh, HJ Lee - International Journal of Molecular …, 2023 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a chronic and refractory interstitial lung disease.
Although there are two approved drugs for IPF, they were not able to completely cure the …

Exploring theophylline-1,2,4-triazole tethered N-phenylacetamide derivatives as antimicrobial agents: unraveling mechanisms via structure-activity relationship, in vitro …

S Saeed, I Shahzadi, AF Zahoor, AA Al-Mutairi… - Frontiers in …, 2024 - frontiersin.org
Theophylline, a nitrogen-containing heterocycle, serves as a promising focal point for
medicinal researchers aiming to create derivatives with diverse pharmacological …

[HTML][HTML] COVID-19-specific transcriptomic signature detectable in blood across multiple cohorts

T Välikangas, S Junttila, KT Rytkönen… - Frontiers in …, 2022 - frontiersin.org
The coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is spreading across the world despite vast global …

Potential hepatoprotective effects of Cistanche deserticola YC Ma: Integrated phytochemical analysis using UPLC-Q-TOF-MS/MS, target network analysis, and …

H Wang, Y Li, Y Bian, X Li, Y Wang, K Wu… - Frontiers in …, 2022 - frontiersin.org
Cistanche deserticola YC Ma (CD) possesses hepatoprotective activity, while the active
ingredients and involved mechanisms have not been fully explored. The objective of this …

[HTML][HTML] One stone two birds: anti-inflammatory bronchodilators as a potential pharmacological strategy for COVID-19

Y Yu, B Fang, XD Yang, Y Zheng - Frontiers in Pharmacology, 2023 - frontiersin.org
The ongoing Coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has imposed a huge threat to public …

Ultra-High Adsorption Capacity of Core–Shell-Derived Magnetic Zeolite Imidazolate Framework-67 as Adsorbent for Selective Extraction of Theophylline

LX Chen, SJ Yin, TQ Chai, JL Wang, GY Chen, X Zhou… - Molecules, 2023 - mdpi.com
A core–shell-derived structural magnetic zeolite imidazolate framework-67 (Fe3O4-COOH@
ZIF-67) nanocomposite was fabricated through a single-step coating of zeolite imidazolate …

Theophylline-Induced Relaxation Is Enhanced after Testosterone Treatment via Increased KV1.2 and KV1.5 Protein Expression in Guinea Pig Tracheal Smooth …

J Reyes-García, V Díaz-Hernández… - International Journal of …, 2023 - mdpi.com
Theophylline is a drug commonly used to treat asthma due to its anti-inflammatory and
bronchodilatory properties. Testosterone (TES) has been suggested to reduce the severity of …

Could the serum glucose/potassium ratio offer an early reliable predictor of life-threatening events in acute methylxanthine intoxication?

AF Sharif, ZA Kasemy, HA Mabrouk… - Toxicology …, 2023 - academic.oup.com
Methylxanthines are widely used to manage pulmonary disorders, particularly in developing
countries. Methylxanthines are unsafe due to their narrow therapeutic index and associated …