A number of epidemiologic studies have described what appear to be paradoxical
associations, where an incongruous relationship is observed between a certain well …

OBJECTIVES: The controversy of CpG island methylator phenotype (CIMP) in colorectal
cancers (CRCs) persists, despite many studies that have been conducted on its correlation …

Disease classification system increasingly incorporates information on pathogenic
mechanisms to predict clinical outcomes and response to therapy and intervention …

Previous studies suggest that abnormal energy balance status may dysregulate intestinal
epithelial homeostasis and promote colorectal carcinogenesis, yet little is known about how …

Background: The influence of anthropometric characteristics on colorectal neoplasia biology
is unclear. We conducted a systematic review and meta-analysis to determine if adult …

Although histochemical staining has been believed to inhibit the DNA amplification reaction,
no previous study has systematically evaluated the influence of histochemical staining on …

Physical exercise results in structural remodeling in tissues and modifies cellular
metabolism. Changes in gene expression lie at the root of these adaptations. Epigenetic …

BACKGROUND Colorectal cancer (CRC) is one of the most common cancers in the world. A
newly proposed integrated pathway comprising traditional, alternate, and serrated pathways …

The CpG Island Methylator Phenotype (CIMP) is fundamental to an important subset of
colorectal cancer; however, its cause is unknown. CIMP is associated with microsatellite …

Background: Physical activity is associated not only with a decreased risk of developing
colorectal cancer but also with improved survival. One putative mechanism is the infiltration …