Fungal infections are an increasing threat to global public health. There are more than six
million fungal species worldwide, but less than 1% are known to infect humans. Most of …

Cryptococcus neoformans is generally considered to be an opportunistic fungal pathogen
because of its tendency to infect immunocompromised individuals, particularly those …

The fungus Cryptococcus neoformans is a leading cause of mortality and morbidity among
HIV-infected individuals. We utilized the completed genome sequence and optimized …

Cryptococcosis is an infectious disease caused by pathogenic encapsulated yeasts in the
genus Cryptococcus. Currently, two species of these fungi commonly cause disease in …

Introduction: The carbonic anhydrases (CAs, EC 4.2. 1.1), a group of ubiquitously expressed
metalloenzymes, are involved in numerous physiological and pathological processes, as …

Cryptococcus neoformans and Cryptococcus gattii are closely related pathogenic fungi that
cause pneumonia and meningitis in both immunocompromised and immunocompetent …

The human pathogenic fungus Cryptococcus neoformans secretes a phospholipase enzyme
that demonstrates phospholipase B (PLB), lysophospholipase hydrolase and …

Our objective was to determine the role of the cryptococcal virulence factor urease in
pulmonary-to-central nervous system, dissemination, invasion, and growth. C. neoformans …

Urea is generated in humans following the breakdown of amino acids and is evenly
distributed throughout the body, including in the central nervous system, subcutaneous …

Cryptococcus neoformans and distantly related fungal species release extracellular vesicles
that traverse the cell wall and contain a varied assortment of components, some of which …