Alterations in cardiac energy metabolism contribute to the severity of heart failure. However,
the energy metabolic changes that occur in heart failure are complex and are dependent not …

Acylcarnitines are fatty acid metabolites that play important roles in many cellular energy
metabolism pathways. They have historically been used as important diagnostic markers for …

Diabetes is a major risk factor for the development of cardiovascular disease via contributing
and/or triggering significant cellular signaling and metabolic and structural alterations at the …

Insulin receptors are highly expressed in the heart and vasculature. Insulin signaling
regulates cardiac growth, survival, substrate uptake, utilization, and mitochondrial …

Alzheimer's disease is a quintessential 'unmet medical need', accounting for∼ 65% of
progressive cognitive impairment among the elderly, and 700,000 deaths in the United …

Backgrounds Branched chain amino acid (BCAA) oxidation is impaired in cardiac insulin
resistance, leading to the accumulation of BCAAs and the first products of BCAA oxidation …

Cardiovascular diseases are the leading cause of death in people with diabetes. Diabetic
cardiomyopathy (DC) is an important complication of diabetes and represents a distinct …

Heart failure (HF) is marked by distinctive changes in myocardial uptake and utilization of
energy substrates. Among the different types of HF, HF with preserved ejection fraction …

Branched-chain amino acids (BCAAs) are essential amino acids which have critical roles in
protein synthesis and energy metabolism in the body. In the heart, there is a strong …

Heart failure and cardiovascular disorders represent the leading cause of death in diabetic
patients. Here we present a systematic review of the main mechanisms underlying the …