Protein aggregation has been recognized as one of the major challenges in the
development and commercialization of successful protein-based drug products because of …

It has been over four decades since the development of monoclonal antibodies (mAbs)
using a hybridoma cell line was first reported. Since then more than thirty therapeutic …

Although it is well known that proteins are only marginally stable in their folded states, it is
often less well appreciated that most proteins are inherently aggregation-prone in their …

In this review, we attempt to give a concise overview of recent progress made in mechanistic
understanding of protein aggregation, particulate formation and protein solution rheology …

Highlights•Therapeutic Abs come from critical screenings of in vivo and in vitro
methods.•Bispecific Abs increase specificity and broaden the range of therapeutic …

Monoclonal antibodies (mAbs) are the fastest-growing biological therapeutics with important
applications ranging from cancers, autoimmunity diseases and metabolic disorders to …

Nano differential scanning fluorimetry (nanoDSF) is a high-throughput protein stability
screening technique that simultaneously monitors protein unfolding and aggregation …

Native mass spectrometry (MS) is a rapidly advancing field in the analysis of proteins,
protein complexes, and macromolecular species of various types. The majority of native MS …

Antibody drugs have been used to treat many diseases, and to date, this has been the most
rapidly growing drug class. However, the lack of suitable methods for real-time and high …

Finding excipients which mitigate protein self-association and aggregation is an important
task during formulation. Here, the effect of an equimolar mixture of l-Arg and l-Glu (Arg· Glu) …