Therapeutic and clinical foundations of cannabidiol therapy for difficult-to-treat seizures in children and adults with refractory epilepsies
DS Reddy - Experimental neurology, 2023 - Elsevier
Novel and effective antiseizure medications are needed to treat refractory and rare forms of
epilepsy. Cannabinoids, which are obtained from the cannabis plant, have a long history of …
epilepsy. Cannabinoids, which are obtained from the cannabis plant, have a long history of …
The many faces of calcineurin inhibitor toxicity—What the FK?
Calcineurin inhibitors (CNIs) are both the savior and Achilles' heel of kidney transplantation.
Although CNIs have significantly reduced rates of acute rejection, their numerous toxicities …
Although CNIs have significantly reduced rates of acute rejection, their numerous toxicities …
Add-on cannabidiol treatment for drug-resistant seizures in tuberous sclerosis complex: a placebo-controlled randomized clinical trial
EA Thiele, EM Bebin, H Bhathal, FE Jansen… - JAMA …, 2021 - jamanetwork.com
Importance Efficacy of cannabidiol has been demonstrated in seizures associated with
Lennox-Gastaut and Dravet syndromes but appears not yet to have been established in …
Lennox-Gastaut and Dravet syndromes but appears not yet to have been established in …
Consensus recommendations on dosing and administration of medical cannabis to treat chronic pain: results of a modified Delphi process
A Bhaskar, A Bell, M Boivin, W Briques… - Journal of cannabis …, 2021 - Springer
Background Globally, medical cannabis legalization has increased in recent years and
medical cannabis is commonly used to treat chronic pain. However, there are few …
medical cannabis is commonly used to treat chronic pain. However, there are few …
Highly purified cannabidiol for epilepsy treatment: A systematic review of epileptic conditions beyond dravet syndrome and Lennox–Gastaut syndrome
Background Cannabidiol (CBD), which is one major constituent of the Cannabis sativa plant,
has anti-seizure properties and does not produce euphoric or intrusive side effects. A plant …
has anti-seizure properties and does not produce euphoric or intrusive side effects. A plant …
Emerging use of epidiolex (cannabidiol) in epilepsy
R Abu-Sawwa, B Scutt, Y Park - The Journal of Pediatric …, 2020 - meridian.allenpress.com
The first plant-derived, purified pharmaceutical-grade cannabidiol (CBD) medication,
Epidiolex, was approved in the United States by the FDA on June 25, 2018. Its approval for …
Epidiolex, was approved in the United States by the FDA on June 25, 2018. Its approval for …
[HTML][HTML] Cannabidiol interactions with medications, illicit substances, and alcohol: a comprehensive review
P Balachandran, M Elsohly, KP Hill - Journal of general internal medicine, 2021 - Springer
Cannabidiol, a non-intoxicating phytocannabinoid, has potential therapeutic effects over a
broad range of disorders. Recently, there has been increased interest in CBD, as several …
broad range of disorders. Recently, there has been increased interest in CBD, as several …
Cannabinoid interactions with cytochrome P450 drug metabolism: a full-spectrum characterization
Medicinal cannabis use has increased exponentially with widespread legalization around
the world. Cannabis-based products are being used for numerous health conditions, often in …
the world. Cannabis-based products are being used for numerous health conditions, often in …
Cannabidiol therapy for refractory epilepsy and seizure disorders
Cannabis-derived cannabinoids have neuroactive properties. Recently, there has been
emerging interest in the use of cannabidiol (CBD)-enriched products for treatment of drug …
emerging interest in the use of cannabidiol (CBD)-enriched products for treatment of drug …
Cytochrome P450–catalyzed metabolism of cannabidiol to the active metabolite 7-hydroxy-cannabidiol
JL Beers, D Fu, KD Jackson - Drug Metabolism and Disposition, 2021 - ASPET
Cannabidiol (CBD) is a naturally occurring nonpsychotoxic phytocannabinoid that has
gained increasing attention as a popular consumer product and for its use in Food and Drug …
gained increasing attention as a popular consumer product and for its use in Food and Drug …