Neuroinflammatory disorders preferentially impair the higher cognitive and executive
functions of the prefrontal cortex (PFC). This includes such challenging disorders as …

P2X3 receptors and group II metabotropic glutamate receptors (mGluRs) have been found to
be expressed in primary sensory neurons. P2X3 receptors participate in a variety of pain …

Purinergic signaling is involved in multiple pain processes. P2X3 receptor is a key target in
pain therapeutics, while A1 adenosine receptor signaling plays a role in analgesia …

Dorsal root ganglia (DRG) neurons transduce and convey somatosensory information from
the periphery to the central nervous system. Adrenergic mediators are known to modulate …

Lysophosphatidic acid (LPA), a lipid metabolite, plays a role in both neuropathic and
inflammatory pain through LPA1 receptors. P2X3 receptor has also been shown to …

Acid-sensing ion channels (ASICs) play an important role in pain associated with tissue
acidification. Peripheral inhibitory group II metabotropic glutamate receptors (mGluRs) have …

Sympathetic overactivity contributes to the pathogenesis of sepsis. The selective α2-
adrenergic receptor agonist dexmedetomidine (DEX) is widely used for perioperative …

Abstract Resolvin D2 (RvD2), an endogenous lipid mediator derived from docosahexaenoic
acid, has been demonstrated to have analgesic effects. However, little is known about the …

A pré-medicação anestésica permite diminuir os níveis de ansiedade dos pacientes,
permitindo uma indução mais suave e uma recuperação pós-cirúrgica mais rápida. Esta …

Lysophosphatidic acid (LPA), a lipid metabolite, plays a role in both neuropathic and in
ammatory pain through LPA1 receptors. P2X3 receptor has also been shown to participate …