Metformin has been the first-line drug for the treatment of type II diabetes mellitus for
decades, being presently the most widely prescribed antihyperglycemic drug. Retrospective …

Background Worldwide, gastric cancer (GC) is the fourth most common malignancy and the
most common cancer in East Asia. Development of targeted therapies for this disease has …

Metformin exerts antitumor effects mainly through AMP-activated protein kinase [AMPK]
activation and phosphatidylinositol 3-kinase [PI3K]-Akt-mammalian target of rapamycin …

OBJECTIVES: Several preclinical and observational studies have shown that anti-diabetic
medications (ADMs) may modify the risk of pancreatic cancer (PaC). We performed a …

Preservation of adult stem cells pools is critical for maintaining tissue homeostasis into old
age. Exhaustion of adult stem cell pools as a result of deranged metabolic signaling …

Phagocytosis of apoptotic cells by myeloid cells has been implicated in the maintenance of
immune homeostasis. In this study, we found that T cell immunoglobulin-and mucin domain …

The occurrence of hepatocellular carcinoma (HCC) is two to three times higher in patients
with diabetes mellitus (DM), the prevalence of which is increasing sharply worldwide. The …

Antidiabetic medication may modify the incidence of hepatocellular carcinoma (HCC). We
aimed to compare the use of different antidiabetic strategies and the incidence of HCC …

Type 2 diabetes mellitus (T2DM), a chronic disease increasing rapidly worldwide, is well
established as an important risk factor for various types of cancer. Although many factors …

The new incretin-based therapies, dipeptidyl peptidase-4 (DPP4) inhibitors and glucagon
like peptide 1 (GLP1) receptor agonists are widely used for the treatment of type 2 diabetes …