Roles of natural killer cells in immunity to cancer, and applications to immunotherapy

NK Wolf, DU Kissiov, DH Raulet - Nature Reviews Immunology, 2023 - nature.com
Great strides have been made in recent years towards understanding the roles of natural
killer (NK) cells in immunity to tumours and viruses. NK cells are cytotoxic innate lymphoid …

Obesity, inflammation, and immune system in osteoarthritis

U Nedunchezhiyan, I Varughese, ARJ Sun… - Frontiers in …, 2022 - frontiersin.org
Obesity remains the most important risk factor for the incidence and progression of
osteoarthritis (OA). The leading cause of OA was believed to be overloading the joints due to …

[HTML][HTML] Nutrition, immunity and COVID-19

PC Calder - BMJ nutrition, prevention & health, 2020 - ncbi.nlm.nih.gov
The immune system protects the host from pathogenic organisms (bacteria, viruses, fungi,
parasites). To deal with this array of threats, the immune system has evolved to include a …

COVID-19 and obesity: dangerous liaisons

G Caci, A Albini, M Malerba, DM Noonan… - Journal of clinical …, 2020 - mdpi.com
Besides advanced age and the presence of multiple comorbidities as major contributors to
increased risk of severe disease and fatal outcome from Severe Acute Respiratory …

[HTML][HTML] Coronavirus disease 2019 (COVID-19) and nutritional status: the missing link?

R Silverio, DC Gonçalves, MF Andrade… - Advances in …, 2021 - Elsevier
ABSTRACT Coronavirus disease 2019 (COVID-19) is an emerging disease that has
reached pandemic status by rapidly spreading worldwide. Elderly individuals and patients …

Innate immunity during SARS-CoV-2: evasion strategies and activation trigger hypoxia and vascular damage

S Amor, L Fernández Blanco… - Clinical & Experimental …, 2020 - academic.oup.com
Innate immune sensing of viral molecular patterns is essential for development of antiviral
responses. Like many viruses, SARS-CoV-2 has evolved strategies to circumvent innate …

Flattening the COVID-19 curve with natural killer cell based immunotherapies

M Market, L Angka, AB Martel, D Bastin… - Frontiers in …, 2020 - frontiersin.org
Natural Killer (NK) cells are innate immune responders critical for viral clearance and
immunomodulation. Despite their vital role in viral infection, the contribution of NK cells in …

Understanding the co-epidemic of obesity and COVID-19: current evidence, comparison with previous epidemics, mechanisms, and preventive and therapeutic …

M Dalamaga, GS Christodoulatos, I Karampela… - Current obesity …, 2021 - Springer
Purpose of Review A growing body of evidence suggests that obesity and increased visceral
adiposity are strongly and independently linked to adverse outcomes and death due to …

[HTML][HTML] Immunomodulatory effect of a very-low-calorie ketogenic diet compared with bariatric surgery and a low-calorie diet in patients with excessive body weight

PM Lorenzo, I Sajoux, AG Izquierdo… - Clinical Nutrition, 2022 - Elsevier
Background & aim Inflammation and oxidative stress are the most probable mechanistic link
between obesity and its co-diseases with cancer among them. The aim of this study was to …

The obese liver environment mediates conversion of NK cells to a less cytotoxic ILC1-like phenotype

AO Cuff, F Sillito, S Dertschnig, A Hall… - Frontiers in …, 2019 - frontiersin.org
The liver contains both NK cells and their less cytotoxic relatives, ILC1. Here, we investigate
the role of NK cells and ILC1 in the obesity-associated condition, non-alcoholic fatty liver …