Covariates in population pharmacokinetic studies of critically ill adults receiving β-lactam antimicrobials: a systematic review and narrative synthesis
Introduction Population pharmacokinetic studies of β-lactam antimicrobials in critically ill
patients derive models that inform their dosing. In non-linear mixed-effects modelling …
patients derive models that inform their dosing. In non-linear mixed-effects modelling …
Achievement of therapeutic antibiotic exposures using Bayesian dosing software in critically unwell children and adults with sepsis
MG Chai, Q Tu, MO Cotta, MJ Bauer, R Balch… - Intensive Care …, 2024 - Springer
Purpose Early recognition and effective treatment of sepsis improves outcomes in critically ill
patients. However, antibiotic exposures are frequently suboptimal in the intensive care unit …
patients. However, antibiotic exposures are frequently suboptimal in the intensive care unit …
Antibiotic combinations prediction based on machine learning to multicentre clinical data and drug interaction correlation
Y Yang, C Ai, Z Ji, W Chen, Y Song, J Zeng… - International Journal of …, 2024 - Elsevier
Background With increasing antibiotic resistance and regulation, the issue of antibiotic
combination has been emphasised. However, antibiotic combination prescribing lacks a …
combination has been emphasised. However, antibiotic combination prescribing lacks a …
Modeling Pharmacokinetics in Individual Patients Using Therapeutic Drug Monitoring and Artificial Population Quasi-Models: A Study with Piperacillin
GB Karvaly, I Vincze, MN Neely, I Zátroch, Z Nagy… - Pharmaceutics, 2024 - mdpi.com
Population pharmacokinetic (pop-PK) models constructed for model-informed precision
dosing often have limited utility due to the low number of patients recruited. To augment …
dosing often have limited utility due to the low number of patients recruited. To augment …
Model-Informed Precision Dosing of Imipenem in an Obese Adolescent Patient with Augmented Renal Clearance and History of Schizophrenia
Y Chen, Y Han, F Guo, Z Yu - Infection and Drug Resistance, 2024 - Taylor & Francis
Imipenem is a broad-spectrum antibiotic that has been used in treating severe infections and
exhibits a time-dependent PK/PD profile. Its dose should be adjusted based on renal …
exhibits a time-dependent PK/PD profile. Its dose should be adjusted based on renal …
Anti-infective prescribing practices in critically ill children on continuous renal replacement therapy: a multicenter survey of French-speaking countries
M Thy, J Naudin, M Genuini, S Leteurtre, M Recher… - Journal of …, 2023 - Springer
Background Use of continuous renal replacement therapy in children receiving anti-infective
drugs may lead to inappropriate concentrations with risks related to treatment failure, toxicity …
drugs may lead to inappropriate concentrations with risks related to treatment failure, toxicity …
[引用][C] Personalising antimicrobial therapy in critically ill patients using Bayesian dosing software
M Chai - 2024 - espace.library.uq.edu.au
Infections in critically ill patients are associated with significant morbidity and mortality
whereby prompt administration of antimicrobials is crucial to help optimise treatment …
whereby prompt administration of antimicrobials is crucial to help optimise treatment …