Kidney fibrosis, characterized by excessive deposition of extracellular matrix (ECM) that
leads to tissue scarring, is the final common outcome of a wide variety of chronic kidney …

Cellular mechanotransduction, a critical regulator of numerous biological processes, is the
conversion from mechanical signals to biochemical signals regarding cell activities and …

The kidney has a remarkable ability of repair after acute kidney injury (AKI). However, when
injury is severe or persistent, the repair is incomplete or maladaptive and may lead to …

Chronic kidney disease (CKD) will become the fifth global cause of death by 2040, thus
emphasizing the need to better understand the molecular mechanisms of damage and …

The kidneys play a key role in maintaining total body homeostasis. The complexity of this
task is reflected in the unique architecture of the organ. Ureteral obstruction greatly affects …

Renal fibrosis is a common progressive manifestation of chronic kidney disease. This
phenomenon of self-repair in response to kidney damage seriously affects the normal …

Background: CCN2 (cellular communication network factor 2) is a matricellular protein
involved in cell communication and microenvironmental signaling responses. CCN2 is …

Background: Renal repair is closely related to the prognosis of acute kidney injury (AKI) and
has attracted increasing attention in the research field. However, there is a lack of a …

Inflammation is a key characteristic of both acute and chronic kidney diseases. Preclinical
data suggest the involvement of the NLRP3/Inflammasome, receptor-interacting protein …

Epigenetics modification is a process that does not change the sequence of
deoxyribonucleic acid (DNA) in disease progression but can alter the genetic expression of …