Cancer is one of the major diseases that cause a high number of deaths globally. Of the
major types of cancers, lung cancer is known to be the most chronic form of cancer in the …

Recent findings suggest that the cellular and extracellular materials surrounding the
cancerous cells from an atypical tumor microenvironment (TM) play a pivotal role in the …

Celastrol, a natural bioactive ingredient derived from Tripterygium wilfordii Hook F, exhibits
significant broad-spectrum anticancer activities for the treatment of a variety of cancers …

Curcumin, a yellow-colored polyphenol extracted from the rhizome of turmeric root, is
commonly used as a spice and nutritional supplement. It exhibits many pharmacological …

Chemotherapy is still a main option for cancer therapy, but its efficacy is often unsatisfying
due to multidrug resistance (MDR). The tumor microenvironment is considered a dominant …

Polyphenols are micronutrients that are widely present in human daily diets. Numerous
studies have demonstrated their potential as antioxidants and anti-inflammatory agents, and …

In the last three decades, radiopharmaceuticals have proven their effectiveness for cancer
diagnosis and therapy. In parallel, the advances in nanotechnology have fueled a plethora …

A huge surge of research is being conducted on combination therapy with anticancer
compounds formulated in the form of nanoparticles (NPs). Numerous advantages like dose …

Recent developments in nanotechnology have brought new approaches to cancer
diagnosis and therapy. While enhanced permeability and retention effect promotes nano …

It is well known that tumors have an acidic pH microenvironment and contain a high content
of hydrogen peroxide (H2O2). These features of the tumor microenvironment may provide …