BACKGROUND Modern reproductive behavior in most developed countries is characterized
by delayed parenthood. Older gametes are generally less fertile, accumulating and …

A remarkable epigenetic remodelling process occurs shortly after fertilization, which restores
totipotency to the zygote. This involves global DNA demethylation, chromatin remodelling …

Abstract In mammals, DNA 5-hydroxymethylcytosine (5hmC) is involved in methylation
reprogramming during early embryonic development. Yet, to what extent 5hmC participates …

Inheritance of genomic DNA underlies the vast majority of biological inheritance, yet it has
been clear for decades that additional epigenetic information can be passed on to future …

DNA methylation is a crucial element in the epigenetic regulation of mammalian embryonic
development,,,,. However, its dynamic patterns have not been analysed at the genome scale …

DNA methylation is a crucial layer of epigenetic regulation during mammalian embryonic
development,–. Although the DNA methylome of early human embryos has been analyzed …

DNA methylation is a defining feature of mammalian cellular identity and is essential for
normal development,. Most cell types, except germ cells and pre-implantation embryos …

Summary H3K9me3, as a hallmark of heterochromatin, is important for cell-fate specification.
However, it remains unknown how H3K9me3 is reprogrammed during human early embryo …

DNA methylation is an epigenetic modification that plays an important role in regulating
gene expression and therefore a broad range of biological processes and diseases. DNA …

DNA methylation is a heritable epigenetic modification involved in gene silencing,
imprinting, and the suppression of retrotransposons. Global DNA demethylation occurs in …