The vascular endothelium is vital in maintaining cardiovascular health by regulating
vascular permeability and tone, preventing thrombosis, and controlling vascular …

Vascular smooth muscle cells (VSMCs) are the predominant cell type in the medial layer of
the aorta, which plays a critical role in the maintenance of aortic wall integrity. VSMCs have …

To improve our limited understanding of the pathogenesis of thoracic aortic aneurysm (TAA)
that leads to acute aortic dissection, single-cell RNA sequencing (scRNA-seq) was …

Marfan syndrome (MFS) is a systemic connective tissue disease that commonly and most
severely affects the ocular, skeletal, and cardiovascular systems. The aim of the manuscript …

Objectives Acknowledging lacking of consensus exist in total aortic arch (TAA) surgery for
acute type A aortic dissection (AAD), this study aimed to investigate the neurologic injury …

Increasing evidence shows that epigenetics also plays a key role in regulating the
pathogenetic mechanism of all types of aortic aneurysms. It is well-known that epigenetic …

Thoracic aortic aneurysm (TAA) has a prevalence of 0.16–0.34% and an incidence of 7.6
per 100,000 person-years, accounting for 1–2% of all deaths in Western countries …

Fibrillin-1 (FBN1) is a large, cysteine-rich, calcium binding extracellular matrix glycoprotein
encoded by FBN1 gene. It serves as a structural component of microfibrils and provides …

Marfan syndrome (MIM:# 154700; MFS) is an autosomal dominant disease representing the
most common form of heritable connective tissue disorder. The condition presents variable …

Aortic aneurysms and dissections (AAD) are devastating aortic diseases with high risks for
aortic rupture, leading to uncontrolled bleeding and death. Despite significant advances in …