AFAP1L1 promotes gastric cancer progression by interacting with VAV2 to facilitate CDC42-mediated activation of ITGA5 signaling pathway
B Sun, B Ding, Y Chen, C Peng, X Chen - Journal of Translational …, 2023 - Springer
Background The actin filament-associated protein (AFAP) family genes include
AFAP1/AFAP-110, AFAP1L1 and AFAP1L2/XB130. Increasing evidence indicates these …
AFAP1/AFAP-110, AFAP1L1 and AFAP1L2/XB130. Increasing evidence indicates these …
A differential diagnosis between uterine leiomyoma and leiomyosarcoma using transcriptome analysis
Background The objective of this study was to estimate the accuracy of transcriptome-based
classifier in differential diagnosis of uterine leiomyoma and leiomyosarcoma. We manually …
classifier in differential diagnosis of uterine leiomyoma and leiomyosarcoma. We manually …
Members of the miR‑30 family inhibit the epithelial‑to‑mesenchymal transition of non‑small‑cell lung cancer cells by suppressing XB130 expression levels
K Song, Y Jiang, Y Zhao, Y Xie, J Zhou… - Oncology …, 2020 - spandidos-publications.com
MicroRNAs (miRs) are associated with cancer metastasis. Aberrant expression levels of
members of the miR‑30 family have been observed in non‑small‑cell lung cancer (NSCLC) …
members of the miR‑30 family have been observed in non‑small‑cell lung cancer (NSCLC) …
A Robust Seven-Gene Signature Associated With Tumor Microenvironment to Predict Survival Outcomes of Patients With Stage III–IV Lung Adenocarcinoma
H Zhao, X Zhang, L Guo, S Shi, C Lu - Frontiers in Genetics, 2021 - frontiersin.org
Background Due to the relatively insidious early symptoms of lung adenocarcinoma (LUAD),
most LUAD patients are at an advanced stage at the time of diagnosis and lose the best …
most LUAD patients are at an advanced stage at the time of diagnosis and lose the best …
XB130, regulated by miR‐203, miR‐219, and miR‐4782‐3p, mediates the proliferation and metastasis of non‐small‐cell lung cancer cells
Q Wang, G Yang, Y Jiang, M Luo, C Li… - Molecular …, 2020 - Wiley Online Library
XB130 is a novel adapter protein that behaves as a tumor promoter or suppressor mediating
cell proliferation and metastasis in the development of different human tumors. Altered …
cell proliferation and metastasis in the development of different human tumors. Altered …
[HTML][HTML] XB130 inhibits healing of diabetic skin ulcers through the PI3K/Akt signalling pathway
XL Zhu, DY Hu, ZX Zeng, WW Jiang… - World Journal of …, 2023 - ncbi.nlm.nih.gov
BACKGROUND Diabetic skin ulcers, a significant global healthcare burden, are mainly
caused by the inhibition of cell proliferation and impaired angiogenesis. XB130 is an …
caused by the inhibition of cell proliferation and impaired angiogenesis. XB130 is an …
The 3'‑untranslated region of XB130 regulates its mRNA stability and translational efficiency in non‑small cell lung cancer cells
Q Wang, L Liu, X Gou, T Zhang, Y Zhao… - Oncology …, 2023 - spandidos-publications.com
Silencing XB130 inhibits cell proliferation and epithelial‑mesenchymal transition in non‑
small cell lung cancer (NSCLC), suggesting that downregulating XB130 expression may …
small cell lung cancer (NSCLC), suggesting that downregulating XB130 expression may …
Molecular mechanism of XB130 adaptor protein mediates trastuzumab resistance in gastric cancer
S Yang, B Wang, J Liao, Z Hong, X Zhong… - Clinical and …, 2023 - Springer
Background Recent studies have shown that the activation of PI3K/AKT signaling pathway is
an essential molecular mechanism participating in trastuzumab resistance in HER2+ GC …
an essential molecular mechanism participating in trastuzumab resistance in HER2+ GC …
Thyroidal transcriptomic profiles of pathoadaptive responses to congenital hypothyroidism in XB130 knockout mice
J Sugihara, A Wong, H Shimizu, J Zhao, HR Cho… - Cells, 2022 - mdpi.com
Congenital hypothyroidism is a genetic condition in which the thyroid gland fails to produce
sufficient thyroid hormone (TH), resulting in metabolic dysfunction and growth retardation …
sufficient thyroid hormone (TH), resulting in metabolic dysfunction and growth retardation …
Pathogenesis of Multinodular Goiter in Elderly XB130-Deficient Mice: Alteration of Thyroperoxidase Affinity with Iodide and Hydrogen Peroxide
HR Cho, J Sugihara, H Shimizu, YY Xiang, X Bai… - Thyroid, 2022 - liebertpub.com
Background: Multinodular goiter (MNG) is the most common disorder of the thyroid gland.
Aging and genetic mutations that impair thyroid hormone (TH) production have been …
Aging and genetic mutations that impair thyroid hormone (TH) production have been …