Expansions of simple tandem repeats are responsible for almost 50 human diseases, the
majority of which are severe, degenerative, and not currently treatable or preventable. In this …

There is broad agreement that genetic influences are central in the development of
idiopathic autism. Whether relatives manifest genetically related milder phenotypes, and if …

Protein tyrosine phosphatases (PTPases), such as SHP-1 and SHP-2, that contain Src
homology 2 (SH2) domains play important roles in growth factor and cytokine signal …

Although inherited p53 mutations are present in all somatic cells, malignant transformation is
limited to certain organs and target cells. The analysis of 475 tumors in 91 families with p53 …

The X-linked androgen receptor (AR) gene contains two polymorphic trinucleotide repeat
segments that code for polyglutamine and polyglycine tracts in the N-terminal trans …

Huntington's disease (HD) is caused by CAG triplet repeat expansion inIT15which leads to
polyglutamine stretches in the HD protein product, huntingtin. The pathological hallmark of …

The mechanism by which polyglutamine expansion in Huntington's disease (HD) results in
selective neuronal degeneration remains unclear. We previously reported that the …

Abstract The isoprostane 8, 12‐iso‐iPF2α‐VI is a sensitive and specific marker of in vivo
lipid peroxidation. We found elevated levels in the urine, blood, and cerebrospinal fluid of …

Synonymous codon usage is biased and the bias seems to be different in different
organisms. Factors with proposed roles in causing codon bias include degree and timing of …

Genetic murine models play an important role in the study of human neurological disorders
by providing accurate and experimentally accessible systems to study pathogenesis and to …