The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …

The liver is crucial for the maintenance of normal glucose homeostasis—it produces glucose
during fasting and stores glucose postprandially. However, these hepatic processes are …

Short (< 10 days) periods of muscle disuse, often necessary for recovery from illness or
injury, lead to various negative health consequences. The current study investigated …

Insulin resistance and muscle mass loss often coincide in individuals with type 2 diabetes.
Most patients with type 2 diabetes are overweight, and it is well established that obesity and …

Lipolysis is the process by which triglycerides (TGs) are hydrolyzed to free fatty acids (FFAs)
and glycerol. In adipocytes, this is achieved by sequential action of adipose TG lipase …

In adipocytes the hydrolysis of TAG to produce fatty acids and glycerol under fasting
conditions or times of elevated energy demands is tightly regulated by neuroendocrine …

Sarcopenia is an age-related disease associated with loss of muscle mass and strength.
This geriatric syndrome predisposes elderly individuals to a disability, falls, fractures, and …

During early pregnancy, embryos must inhibit the development of the luteolytic mechanism
to maintain the secretion of progesterone necessary for continuing development. Thus …

Adipocyte progenitor cells (APCs) provide the reservoir of regenerative cells to produce new
adipocytes, although their identity in humans remains elusive. Using FACS analysis, gene …

Intermuscular adipose tissue (IMAT) is negatively related to insulin sensitivity, but a causal
role of IMAT in the development of insulin resistance is unknown. IMAT was sampled in …