The transmission of a complete set of chromosomes to daughter cells during cell division is
vital for development and tissue homeostasis. The spindle assembly checkpoint (SAC) …

Mitotic cell division is tightly monitored by checkpoints that safeguard the genome from
instability. Failures in accurate chromosome segregation during mitosis can cause …

Understanding the basis for cellular growth, proliferation, and function requires determining
the roles of essential genes in diverse cellular processes, including visualizing their …

Kinetochores are molecular machines that power chromosome segregation during the
mitotic and meiotic cell divisions of all eukaryotes. Aristotle explains how we think we have …

Faithful chromosome segregation requires robust, load-bearing attachments of
chromosomes to the mitotic spindle, a function accomplished by large macromolecular …

Mitotic defects activate the spindle-assembly checkpoint, which inhibits the anaphase-
promoting complex co-activator CDC20 to induce a prolonged cell cycle arrest,. Once errors …

Enduring chromosome segregation errors represent potential threats to genomic stability
due to eventual chromosome copy number alterations (aneuploidy) and formation of …

Chromosome biorientation on the mitotic spindle is prerequisite to errorless genome
inheritance. CENP‐E (kinesin‐7) and dynein–dynactin (DD), microtubule motors with …

Chromosome alignment to the spindle equator is a hallmark of mitosis thought to promote
chromosome segregation fidelity in metazoans. Yet chromosome alignment is only indirectly …

It has been proposed that ATR kinase senses the completion of DNA replication to initiate
the S/G2 transition. In contrast to this model, we show here that the TRESLIN-MTBP complex …