Activated fibroblasts in tumors, or cancer-associated fibroblasts (CAFs), have become a
popular research area over the past decade. As important players in many aspects of tumor …

Nonalcoholic fatty liver disease is the most prevalent liver disease worldwide, affecting 20%–
25% of the adult population. In 25% of patients, nonalcoholic fatty liver disease progresses …

Adult hepatocyte identity is constructed throughout embryonic development and fine-tuned
after birth. A multinodular network of transcription factors, along with pre-mRNA splicing …

Background Despite integrin being highlighted as a stiffness‐sensor molecule in matrix
stiffness‐driven angiogenesis, other stiffness‐sensor molecules and their mechanosensory …

Objective Hepatocellular carcinoma (HCC) is a prevalent and aggressive cancer usually
arising on a background of chronic liver injury involving inflammatory and hepatic …

Cancer research has been largely focused on the cellular and molecular levels of
investigation. Recent data show that not only the cell but also the extracellular matrix plays a …

Mechanobiology is a domain of interdisciplinary research that aims to explore the impact of
physical force, applied externally or internally, on cell and tissue function, including …

Pancreatic ductal adenocarcinoma (PDAC) features high recurrence rates and intensified
lethality, accompanied by stiffening of the extracellular matrix (ECM) microenvironment …

Accumulation of fibroblasts in the premalignant or malignant liver is a characteristic feature
of liver cancer, but has not been therapeutically leveraged despite evidence for …

Matrix stiffness is a key physical characteristic of the tumor microenvironment and correlates
tightly with tumor progression. Here, we explored the association between matrix stiffness …