Activated fibroblasts in cancer: Perspectives and challenges
G Caligiuri, DA Tuveson - Cancer cell, 2023 - cell.com
Activated fibroblasts in tumors, or cancer-associated fibroblasts (CAFs), have become a
popular research area over the past decade. As important players in many aspects of tumor …
popular research area over the past decade. As important players in many aspects of tumor …
Mechanisms of fibrosis development in nonalcoholic steatohepatitis
Nonalcoholic fatty liver disease is the most prevalent liver disease worldwide, affecting 20%–
25% of the adult population. In 25% of patients, nonalcoholic fatty liver disease progresses …
25% of the adult population. In 25% of patients, nonalcoholic fatty liver disease progresses …
[HTML][HTML] Loss of liver function in chronic liver disease: An identity crisis
Adult hepatocyte identity is constructed throughout embryonic development and fine-tuned
after birth. A multinodular network of transcription factors, along with pre-mRNA splicing …
after birth. A multinodular network of transcription factors, along with pre-mRNA splicing …
Activation of Piezo1 contributes to matrix stiffness‐induced angiogenesis in hepatocellular carcinoma
M Li, X Zhang, M Wang, Y Wang, J Qian… - Cancer …, 2022 - Wiley Online Library
Background Despite integrin being highlighted as a stiffness‐sensor molecule in matrix
stiffness‐driven angiogenesis, other stiffness‐sensor molecules and their mechanosensory …
stiffness‐driven angiogenesis, other stiffness‐sensor molecules and their mechanosensory …
[HTML][HTML] TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms
A Esparza-Baquer, I Labiano, O Sharif, A Agirre-Lizaso… - Gut, 2021 - gut.bmj.com
Objective Hepatocellular carcinoma (HCC) is a prevalent and aggressive cancer usually
arising on a background of chronic liver injury involving inflammatory and hepatic …
arising on a background of chronic liver injury involving inflammatory and hepatic …
Biology of cancer; from cellular and molecular mechanisms to developmental processes and adaptation
IG Motofei - Seminars in Cancer Biology, 2022 - Elsevier
Cancer research has been largely focused on the cellular and molecular levels of
investigation. Recent data show that not only the cell but also the extracellular matrix plays a …
investigation. Recent data show that not only the cell but also the extracellular matrix plays a …
Mechanotransduction in the pathogenesis of non-alcoholic fatty liver disease
EK Mitten, G Baffy - Journal of Hepatology, 2022 - Elsevier
Mechanobiology is a domain of interdisciplinary research that aims to explore the impact of
physical force, applied externally or internally, on cell and tissue function, including …
physical force, applied externally or internally, on cell and tissue function, including …
Biomimetic microenvironmental stiffness boosts stemness of pancreatic ductal adenocarcinoma via augmented autophagy
T Gong, D Wu, H Pan, Z Sun, X Yao… - ACS Biomaterials …, 2023 - ACS Publications
Pancreatic ductal adenocarcinoma (PDAC) features high recurrence rates and intensified
lethality, accompanied by stiffening of the extracellular matrix (ECM) microenvironment …
lethality, accompanied by stiffening of the extracellular matrix (ECM) microenvironment …
Fibroblasts in liver cancer: functions and therapeutic translation
Accumulation of fibroblasts in the premalignant or malignant liver is a characteristic feature
of liver cancer, but has not been therapeutically leveraged despite evidence for …
of liver cancer, but has not been therapeutically leveraged despite evidence for …
[HTML][HTML] Matrix stiffness promotes glioma cell stemness by activating BCL9L/Wnt/β-catenin signaling
B Tao, Y Song, Y Wu, X Yang, T Peng, L Peng… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Matrix stiffness is a key physical characteristic of the tumor microenvironment and correlates
tightly with tumor progression. Here, we explored the association between matrix stiffness …
tightly with tumor progression. Here, we explored the association between matrix stiffness …