Depression in patients with Parkinson's disease: current understanding of its neurobiology and implications for treatment
S Prange, H Klinger, C Laurencin, T Danaila… - Drugs & Aging, 2022 - Springer
Depression is one of the most frequent and burdensome non-motor symptoms in
Parkinson's disease (PD), across all stages. Even when its severity is mild, PD depression …
Parkinson's disease (PD), across all stages. Even when its severity is mild, PD depression …
Apathy in Parkinson's disease: clinical features, neural substrates, diagnosis, and treatment
J Pagonabarraga, J Kulisevsky, AP Strafella… - The Lancet …, 2015 - thelancet.com
Normal maintenance of human motivation depends on the integrity of subcortical structures
that link the prefrontal cortex with the limbic system. Structural and functional disruption of …
that link the prefrontal cortex with the limbic system. Structural and functional disruption of …
A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015
LM Chahine, AW Amara, A Videnovic - Sleep medicine reviews, 2017 - Elsevier
Sleep disorders are among the most common non-motor manifestations in Parkinson's
disease (PD) and have a significant negative impact on quality of life. While sleep disorders …
disease (PD) and have a significant negative impact on quality of life. While sleep disorders …
Apathy in Parkinson's disease: a systematic review and meta‐analysis
MGHE Den Brok, JW van Dalen… - Movement …, 2015 - Wiley Online Library
Apathy is a frequently reported neuropsychiatric symptom in Parkinson's disease (PD), but
its prevalence and clinical correlates are debated. We aimed to address these issues by …
its prevalence and clinical correlates are debated. We aimed to address these issues by …
Depression in Parkinson disease—epidemiology, mechanisms and management
D Aarsland, S Påhlhagen, CG Ballard, U Ehrt… - Nature Reviews …, 2012 - nature.com
Depression occurs in around 35% of patients with Parkinson disease (PD) and is often
persistent. Symptoms of depression can be evident in individuals at the time of diagnosis …
persistent. Symptoms of depression can be evident in individuals at the time of diagnosis …
Initial clinical manifestations of Parkinson's disease: features and pathophysiological mechanisms
MC Rodriguez-Oroz, M Jahanshahi, P Krack… - The Lancet …, 2009 - thelancet.com
A dopaminergic deficiency in patients with Parkinson's disease (PD) causes abnormalities of
movement, behaviour, learning, and emotions. The main motor features (ie, tremor, rigidity …
movement, behaviour, learning, and emotions. The main motor features (ie, tremor, rigidity …
[HTML][HTML] The relationship between stress and Alzheimer's disease
NJ Justice - Neurobiology of stress, 2018 - Elsevier
Stress is critically involved in the development and progression of disease. From the stress
of undergoing treatments to facing your own mortality, the physiological processes that …
of undergoing treatments to facing your own mortality, the physiological processes that …
Parkinson's disease psychosis: presentation, diagnosis and management
RB Schneider, J Iourinets, IH Richard - Neurodegenerative …, 2017 - Taylor & Francis
Parkinson's disease is a neurodegenerative disorder characterized by motor and nonmotor
symptoms. Psychosis is a common feature of Parkinson's disease. Parkinson's disease …
symptoms. Psychosis is a common feature of Parkinson's disease. Parkinson's disease …
Minor hallucinations occur in drug‐naive Parkinson's disease patients, even from the premotor phase
J Pagonabarraga, S Martinez‐Horta… - Movement …, 2016 - Wiley Online Library
Objectives The description of minor hallucinatory phenomena (presence, passage
hallucinations) has widened the spectrum of psychosis in Parkinson's disease (PD). Minor …
hallucinations) has widened the spectrum of psychosis in Parkinson's disease (PD). Minor …
Cognitive-behavioral therapy for depression in Parkinson's disease: a randomized, controlled trial
Objective: Despite the negative effects of depression in Parkinson's disease, there is
currently no evidence-based standard of care. The purpose of this study was to examine the …
currently no evidence-based standard of care. The purpose of this study was to examine the …