[HTML][HTML] Applications of single-cell RNA sequencing in drug discovery and development
B Van de Sande, JS Lee, E Mutasa-Gottgens… - Nature Reviews Drug …, 2023 - nature.com
Single-cell technologies, particularly single-cell RNA sequencing (scRNA-seq) methods,
together with associated computational tools and the growing availability of public data …
together with associated computational tools and the growing availability of public data …
Understanding tumour endothelial cell heterogeneity and function from single-cell omics
Q Zeng, M Mousa, AS Nadukkandy, L Franssens… - Nature Reviews …, 2023 - nature.com
Anti-angiogenic therapies (AATs) are used to treat different types of cancers. However, their
success is limited owing to insufficient efficacy and resistance. Recently, single-cell omics …
success is limited owing to insufficient efficacy and resistance. Recently, single-cell omics …
Identification of a tumour immune barrier in the HCC microenvironment that determines the efficacy of immunotherapy
Y Liu, Z Xun, K Ma, S Liang, X Li, S Zhou, L Sun… - Journal of …, 2023 - Elsevier
Background & Aims The tumour microenvironment (TME) is a crucial mediator of cancer
progression and therapeutic outcome. The TME subtype correlates with patient response to …
progression and therapeutic outcome. The TME subtype correlates with patient response to …
[HTML][HTML] Single-cell spatial landscapes of the lung tumour immune microenvironment
Single-cell technologies have revealed the complexity of the tumour immune
microenvironment with unparalleled resolution,,,,,,,–. Most clinical strategies rely on …
microenvironment with unparalleled resolution,,,,,,,–. Most clinical strategies rely on …
[PDF][PDF] Histopathologic and proteogenomic heterogeneity reveals features of clear cell renal cell carcinoma aggressiveness
Clear cell renal cell carcinomas (ccRCCs) represent∼ 75% of RCC cases and account for
most RCC-associated deaths. Inter-and intratumoral heterogeneity (ITH) results in varying …
most RCC-associated deaths. Inter-and intratumoral heterogeneity (ITH) results in varying …
[HTML][HTML] Epigenetic and transcriptomic characterization reveals progression markers and essential pathways in clear cell renal cell carcinoma
Identifying tumor-cell-specific markers and elucidating their epigenetic regulation and spatial
heterogeneity provides mechanistic insights into cancer etiology. Here, we perform snRNA …
heterogeneity provides mechanistic insights into cancer etiology. Here, we perform snRNA …
[HTML][HTML] Reconstruction of the tumor spatial microenvironment along the malignant-boundary-nonmalignant axis
Z Xun, X Ding, Y Zhang, B Zhang, S Lai, D Zou… - Nature …, 2023 - nature.com
Although advances in spatial transcriptomics (ST) enlarge to unveil spatial landscape of
tissues, it remains challenging to delineate pathology-relevant and cellular localizations …
tissues, it remains challenging to delineate pathology-relevant and cellular localizations …
[HTML][HTML] Updates on immunotherapy and immune landscape in renal clear cell carcinoma
Simple Summary Clear cell renal cell carcinomas (ccRCC) have several distinct
immunological features, including a high degree of immune infiltration and relatively low …
immunological features, including a high degree of immune infiltration and relatively low …
Mapping the human kidney using single-cell genomics
F Schreibing, R Kramann - Nature Reviews Nephrology, 2022 - nature.com
The field of single-cell genomics and spatial technologies is rapidly evolving and has
already provided unprecedented insights into complex tissues. Major advances have been …
already provided unprecedented insights into complex tissues. Major advances have been …
Fatty acid metabolism reprogramming in ccRCC: mechanisms and potential targets
Lipid droplet formation is a defining histological feature in clear-cell renal cell carcinoma
(ccRCC) but the underlying mechanisms and importance of this biological behaviour have …
(ccRCC) but the underlying mechanisms and importance of this biological behaviour have …