Rapid and in situ profiling of volatile metabolites from body fluids represents a new trend in
cancer diagnosis and classification in the early stages. We report herein an on-chip strategy …

Background: Early detection and precise prognostic evaluation of clear cell renal cell
carcinoma (ccRCC) are crucial for patient life expectancy. Ion channel-related genes …

Simple Summary In recent years, several therapeutic advances have been made in clear
cell renal cell carcinoma (ccRCC) resulting in novel treatment regimens of increased …

Cancer is partly a developmental disease, with malignancies named based on cell or tissue
of origin. However, a systematic atlas of tumor origins is lacking. Here we map the single-cell …

Spatial transcriptomics technologies with high resolution often lack high sensitivity in mRNA
detection. Here we report a dendrimeric DNA coordinate barcoding design for spatial RNA …

Overexpression of actin-binding protein profilin-1 (Pfn1) correlates with advanced disease
features and adverse clinical outcome of patients with clear cell renal carcinoma, the most …

Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer, and it
is the major cause of kidney cancer death. Understanding tumor immune microenvironments …

Caspase-1 signaling in myeloid suppressor cells can promote T-cell independent cancer
progression, but the regulation of inflammasome signaling within the highly heterogeneous …

Introduction: Clear cell renal cell carcinoma (ccRCC) is associated with unfavorable clinical
outcomes. To identify viable therapeutic targets, a comprehensive understanding of …

Simple Summary A several immunotherapy-based combinations regimen improved overall
survival, and became the new first-line standard of care for metastatic clear cell renal cell …