Spontaneous preterm birth: Involvement of multiple feto-maternal tissues and organ systems, differing mechanisms, and pathways

MS Vidal Jr, RCV Lintao, MEL Severino… - Frontiers in …, 2022 - frontiersin.org
Survivors of preterm birth struggle with multitudes of disabilities due to improper in utero
programming of various tissues and organ systems contributing to adult-onset diseases at a …

Fetal inflammatory response at the fetomaternal interface: A requirement for labor at term and preterm

R Menon - Immunological reviews, 2022 - Wiley Online Library
Human parturition at term and preterm is an inflammatory process synchronously executed
by both fetomaternal tissues to transition them from a quiescent state t an active state of …

[HTML][HTML] Macrophages exert homeostatic actions in pregnancy to protect against preterm birth and fetal inflammatory injury

N Gomez-Lopez, V Garcia-Flores, PY Chin… - JCI insight, 2021 - ncbi.nlm.nih.gov
Macrophages are commonly thought to contribute to the pathophysiology of preterm labor by
amplifying inflammation—but a protective role has not previously been considered to our …

A key role for NLRP3 signaling in preterm labor and birth driven by the alarmin S100B

J Galaz, K Motomura, R Romero, Z Liu… - Translational …, 2023 - Elsevier
Preterm birth remains the leading cause of neonatal morbidity and mortality worldwide. A
substantial number of spontaneous preterm births occur in the context of sterile intra …

[HTML][HTML] Fetal and maternal NLRP3 signaling is required for preterm labor and birth

K Motomura, R Romero, J Galaz, L Tao… - JCI insight, 2022 - ncbi.nlm.nih.gov
Preterm birth is the leading cause of neonatal morbidity and mortality worldwide. One of
every 4 preterm neonates is born to a mother with intra-amniotic inflammation driven by …

[HTML][HTML] Interactions between microbiota and cervical epithelial, immune, and mucus barrier

M Dong, Y Dong, J Bai, H Li, X Ma, B Li… - Frontiers in cellular …, 2023 - frontiersin.org
The female reproductive tract harbours hundreds of bacterial species and produces
numerous metabolites. The uterine cervix is located between the upper and lower parts of …

Mueller matrix imaging for collagen scoring in mice model of pregnancy

HR Lee, I Saytashev, VN Du Le, M Mahendroo… - Scientific reports, 2021 - nature.com
Preterm birth risk is associated with early softening of the uterine cervix in pregnancy due to
the accelerated remodeling of collagen extracellular matrix. Studies of mice model of …

Parity and gestational age are associated with vaginal microbiota composition in term and late term pregnancies

K Kervinen, T Holster, S Saqib, S Virtanen… - …, 2022 - thelancet.com
Background Vaginal microbiota and its potential contribution to preterm birth is under
intense research. However, only few studies have investigated the vaginal microbiota in …

[HTML][HTML] Modeling ascending Ureaplasma parvum infection through the female reproductive tract using vagina-cervix-decidua-organ-on-a-chip and feto-maternal …

OAG Tantengco, LS Richardson… - … : official publication of …, 2022 - ncbi.nlm.nih.gov
Genital mycoplasmas can break the cervical barrier and cause intraamniotic infection and
preterm birth. This study developed a six-chamber vagina-cervix-decidua-organ-on-a-chip …

Parturition in mammals: Animal models, pain and distress

J Martínez-Burnes, R Muns, H Barrios-García… - Animals, 2021 - mdpi.com
Simple Summary Labour is considered a painful episode where complex physiological,
hormonal, morphological, and behavioural changes are present. During animal parturition …