The role of m6A methylation in therapy resistance in cancer

H Zhuang, B Yu, D Tao, X Xu, Y Xu, J Wang, Y Jiao… - Molecular cancer, 2023 - Springer
Cancer therapy resistance is the main cause of cancer treatment failure. The mechanism of
therapy resistance is a hot topic in epigenetics. As one of the most common RNA …

A highly annotated database of genes associated with platinum resistance in cancer

D Huang, SR Savage, AP Calinawan, C Lin, B Zhang… - Oncogene, 2021 - nature.com
Platinum-based chemotherapy, including cisplatin, carboplatin, and oxaliplatin, is prescribed
to 10-20% of all cancer patients. Unfortunately, platinum resistance develops in a significant …

The Warburg effect: a score for many instruments in the concert of cancer and cancer niche cells

M Jaworska, J Szczudło, A Pietrzyk, J Shah… - Pharmacological …, 2023 - Springer
Although Warburg's discovery of intensive glucose uptake by tumors, followed by lactate
fermentation in oxygen presence of oxygen was made a century ago, it is still an area of …

Photooxidation triggered ultralong afterglow in carbon nanodots

GS Zheng, CL Shen, CY Niu, Q Lou, TC Jiang… - Nature …, 2024 - nature.com
It remains a challenge to obtain biocompatible afterglow materials with long emission
wavelengths, durable lifetimes, and good water solubility. Herein we develop a …

Hypoxia signaling in hepatocellular carcinoma: Challenges and therapeutic opportunities

SQ Sin, CD Mohan, RMWJ Goh, M You… - Cancer and Metastasis …, 2023 - Springer
Hepatocellular carcinoma (HCC) is one of the most common cancers with a relatively high
cancer-related mortality. The uncontrolled proliferation of HCC consumes a significant …

(Im) maturity in tumor ecosystem

K Mortezaee, J Majidpoor - Frontiers in oncology, 2022 - frontiersin.org
Tumors have special features that make them distinct from their normal counterparts.
Immature cells in a tumor mass and their critical contributions to the tumorigenesis will open …

Metabolic adaptation of NK cell activity and behavior in tumors: challenges and therapeutic opportunities

S Borde, S Matosevic - Trends in Pharmacological Sciences, 2023 - cell.com
The adaptation of natural killer (NK) cells to conditions in the microenvironment of tumors is
deeply affected by their metabolic activity, itself a result of nutrient availability and the …

[HTML][HTML] Metabolic therapy and bioenergetic analysis: The missing piece of the puzzle

T Duraj, J Carrión-Navarro, TN Seyfried… - Molecular …, 2021 - Elsevier
Background Aberrant metabolism is recognized as a hallmark of cancer, a pillar necessary
for cellular proliferation. Regarding bioenergetics (ATP generation), most cancers display a …

An appraisal of the current status of inhibition of glucose transporters as an emerging antineoplastic approach: Promising potential of new pan-GLUT inhibitors

MK Temre, A Kumar, SM Singh - Frontiers in Pharmacology, 2022 - frontiersin.org
Neoplastic cells displayed altered metabolism with accelerated glycolysis. Therefore, these
cells need a mammoth supply of glucose for which they display an upregulated expression …

[HTML][HTML] Targeting lymphangiogenesis and lymph node metastasis in liver cancer

S Roy, P Banerjee, B Ekser, K Bayless… - The American Journal of …, 2021 - Elsevier
Increased lymphangiogenesis and lymph node metastasis, the important prognostic
indicators of aggressive hepatobiliary malignancies such as hepatocellular cancer and …