[HTML][HTML] Small molecules in targeted cancer therapy: advances, challenges, and future perspectives
L Zhong, Y Li, L Xiong, W Wang, M Wu… - Signal transduction and …, 2021 - nature.com
Due to the advantages in efficacy and safety compared with traditional chemotherapy drugs,
targeted therapeutic drugs have become mainstream cancer treatments. Since the first …
targeted therapeutic drugs have become mainstream cancer treatments. Since the first …
A study of miRNAs as cornerstone in lung cancer pathogenesis and therapeutic resistance: A focus on signaling pathways interplay
Lung cancer (LC) is the most common cancer-related death globally, and many efforts have
been made to improve the patient care of LC patients, as well as the development of efficient …
been made to improve the patient care of LC patients, as well as the development of efficient …
[HTML][HTML] Advances and challenges in the treatment of lung cancer
Y Li, B Yan, S He - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Lung cancer accounts for a relatively high proportion of malignant tumors. As the most
prevalent type of lung cancer, non-small cell lung cancer (NSCLC) is characterized by high …
prevalent type of lung cancer, non-small cell lung cancer (NSCLC) is characterized by high …
Drug resistance to targeted therapeutic strategies in non-small cell lung cancer
Rapidly developing molecular biology techniques have been employed to identify cancer
driver genes in specimens from patients with non-small cell lung cancer (NSCLC). Inhibitors …
driver genes in specimens from patients with non-small cell lung cancer (NSCLC). Inhibitors …
Transcriptome‐level discovery of survival‐associated biomarkers and therapy targets in non‐small‐cell lung cancer
B Győrffy - British Journal of Pharmacology, 2024 - Wiley Online Library
Abstract Background and Purpose Survival rate of patients with lung cancer has increased
by over 60% in the recent two decades. With longer survival, the identification of genes …
by over 60% in the recent two decades. With longer survival, the identification of genes …
Utilization of polymer-lipid hybrid nanoparticles for targeted anti-cancer therapy
Cancer represents one of the most dangerous diseases, with 1.8 million deaths worldwide.
Despite remarkable advances in conventional therapies, these treatments are not effective …
Despite remarkable advances in conventional therapies, these treatments are not effective …
Triple negative breast cancer and non-small cell lung cancer: Clinical challenges and nano-formulation approaches
Triple negative breast cancer (TNBC) and non-small cell lung cancer (NSCLC) are amongst
the most aggressive forms of solid tumors. TNBC is highlighted by absence of genetic …
the most aggressive forms of solid tumors. TNBC is highlighted by absence of genetic …
Pyrimidine-based EGFR TK inhibitors in targeted cancer therapy
Despite significant improvements of new treatment options, cancer continues to represent as
one of the most common and fatal disease. The EGFR signaling pathway is considered as a …
one of the most common and fatal disease. The EGFR signaling pathway is considered as a …
Role of exosomal microRNAs in lung cancer biology and clinical applications
C Hu, S Meiners, C Lukas, GT Stathopoulos… - Cell …, 2020 - Wiley Online Library
Exosomes, small extracellular vesicles ranging from 30 to 150 nm, are secreted by various
cell types, including tumour cells. Recently, microRNAs (miRNAs) were identified to be …
cell types, including tumour cells. Recently, microRNAs (miRNAs) were identified to be …
Primary and acquired resistance to immunotherapy in lung cancer: unveiling the mechanisms underlying of immune checkpoint blockade therapy
L Boyero, A Sánchez-Gastaldo, M Alonso… - Cancers, 2020 - mdpi.com
Simple Summary Immuno-oncology has redefined the treatment of lung cancer, with the
ultimate goal being the reactivation of the anti-tumor immune response. This has led to the …
ultimate goal being the reactivation of the anti-tumor immune response. This has led to the …