[HTML][HTML] Small molecules in targeted cancer therapy: advances, challenges, and future perspectives

L Zhong, Y Li, L Xiong, W Wang, M Wu… - Signal transduction and …, 2021 - nature.com
Due to the advantages in efficacy and safety compared with traditional chemotherapy drugs,
targeted therapeutic drugs have become mainstream cancer treatments. Since the first …

A study of miRNAs as cornerstone in lung cancer pathogenesis and therapeutic resistance: A focus on signaling pathways interplay

AS Doghish, A Ismail, MA Elrebehy… - … -Research and Practice, 2022 - Elsevier
Lung cancer (LC) is the most common cancer-related death globally, and many efforts have
been made to improve the patient care of LC patients, as well as the development of efficient …

[HTML][HTML] Advances and challenges in the treatment of lung cancer

Y Li, B Yan, S He - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Lung cancer accounts for a relatively high proportion of malignant tumors. As the most
prevalent type of lung cancer, non-small cell lung cancer (NSCLC) is characterized by high …

Drug resistance to targeted therapeutic strategies in non-small cell lung cancer

W Liu, Y Du, R Wen, M Yang, J Xu - Pharmacology & therapeutics, 2020 - Elsevier
Rapidly developing molecular biology techniques have been employed to identify cancer
driver genes in specimens from patients with non-small cell lung cancer (NSCLC). Inhibitors …

Transcriptome‐level discovery of survival‐associated biomarkers and therapy targets in non‐small‐cell lung cancer

B Győrffy - British Journal of Pharmacology, 2024 - Wiley Online Library
Abstract Background and Purpose Survival rate of patients with lung cancer has increased
by over 60% in the recent two decades. With longer survival, the identification of genes …

Utilization of polymer-lipid hybrid nanoparticles for targeted anti-cancer therapy

A Mohanty, S Uthaman, IK Park - Molecules, 2020 - mdpi.com
Cancer represents one of the most dangerous diseases, with 1.8 million deaths worldwide.
Despite remarkable advances in conventional therapies, these treatments are not effective …

Triple negative breast cancer and non-small cell lung cancer: Clinical challenges and nano-formulation approaches

S Ghosh, A Javia, S Shetty, D Bardoliwala… - Journal of Controlled …, 2021 - Elsevier
Triple negative breast cancer (TNBC) and non-small cell lung cancer (NSCLC) are amongst
the most aggressive forms of solid tumors. TNBC is highlighted by absence of genetic …

Pyrimidine-based EGFR TK inhibitors in targeted cancer therapy

A Ayati, S Moghimi, M Toolabi, A Foroumadi - European Journal of …, 2021 - Elsevier
Despite significant improvements of new treatment options, cancer continues to represent as
one of the most common and fatal disease. The EGFR signaling pathway is considered as a …

Role of exosomal microRNAs in lung cancer biology and clinical applications

C Hu, S Meiners, C Lukas, GT Stathopoulos… - Cell …, 2020 - Wiley Online Library
Exosomes, small extracellular vesicles ranging from 30 to 150 nm, are secreted by various
cell types, including tumour cells. Recently, microRNAs (miRNAs) were identified to be …

Primary and acquired resistance to immunotherapy in lung cancer: unveiling the mechanisms underlying of immune checkpoint blockade therapy

L Boyero, A Sánchez-Gastaldo, M Alonso… - Cancers, 2020 - mdpi.com
Simple Summary Immuno-oncology has redefined the treatment of lung cancer, with the
ultimate goal being the reactivation of the anti-tumor immune response. This has led to the …