Galanin (2–11) binds to GalR3 in transfected cell lines: limitations for pharmacological definition of receptor subtypes

X Lu, L Lundström, T Bartfai - Neuropeptides, 2005 - Elsevier
The neuropeptide galanin regulates a variety of physiological and pathophysiological
processes through three G protein coupled receptors, GalR1, GalR2, and GalR3. The …

Molecular pathophysiology of cavernous nerve injury and identification of strategies for nerve function recovery after radical prostatectomy

E Weyne, J Mulhall, M Albersen - Current drug targets, 2015 - ingentaconnect.com
Despite nerve-sparing techniques, erectile dysfunction remains commonly observed after
radical prostatectomy due to neuropraxia to the cavernous nerves during surgery …

The axotomy‐induced neuropeptides galanin and pituitary adenylate cyclase‐activating peptide promote axonal sprouting of primary afferent and cranial motor …

V Suarez, O Guntinas‐Lichius… - European Journal of …, 2006 - Wiley Online Library
The neuropeptides galanin and pituitary adenylate cyclase‐activating peptide (PACAP) are
markedly up‐regulated in response to peripheral nerve lesion. Both peptides are involved in …

Neuroprotective role for galanin in Alzheimer's disease

SE Counts, SE Perez, SD Ginsberg, EJ Mufson - Galanin, 2010 - Springer
Galanin (GAL) and GAL receptors (GALR) are overexpressed in degenerating brain regions
associated with cognitive decline in Alzheimer's disease (AD). The functional consequences …

'Neuro'-peptides in glia: focus on NPY and galanin

R Ubink, L Calza, T Hökfelt - Trends in neurosciences, 2003 - cell.com
The term neuropeptide was advanced by de Wied and collaborators in the early seventies.
At that time, they defined neuropeptides as endogenous substances synthesized in nerve …

Sensory neuronal phenotype in galanin receptor 2 knockout mice: focus on dorsal root ganglion neurone development and pain behaviour

TJS Shi, X Hua, X Lu, S Malkmus… - European Journal of …, 2006 - Wiley Online Library
Galanin is a 29‐amino‐acid peptide expressed in dorsal root ganglion (DRG) neurones and
spinal dorsal horn neurones. It affects pain threshold and has developmental and trophic …

Developing novel antiepileptic drugs: characterization of NAX 5055, a systemically-active galanin analog, in epilepsy models

HS White, EA Scholl, BD Klein, SP Flynn, TH Pruess… - …, 2009 - Springer
The endogenous neuropeptide galanin and its associated receptors galanin receptor 1 and
galanin receptor 2 are highly localized in brain limbic structures and play an important role …

Involvement of neuropeptide galanin receptors 2 and 3 in learning, memory and anxiety in aging mice

F Locker, L Bieler, LMF Nowack, J Leitner, SM Brunner… - Molecules, 2021 - mdpi.com
The neuropeptide galanin (GAL), which is expressed in limbic brain structures, has a strong
impact on the regulation of mood and behavior. GAL exerts its effects via three G protein …

Use of genetically engineered transgenic mice to investigate the role of galanin in the peripheral nervous system after injury

FE Holmes, SA Mahoney, D Wynick - Neuropeptides, 2005 - Elsevier
The neuropeptide galanin is present at high levels within the dorsal root ganglia (DRG) and
spinal cord during development and after peripheral nerve damage in the adult. This pattern …

Generation and phenotypic characterization of a galanin overexpressing mouse

K Holmberg, E Kuteeva, P Brumovsky, U Kahl… - Neuroscience, 2005 - Elsevier
In most parts of the peripheral nervous system galanin is expressed at very low levels. To
further understand the functional role of galanin, a mouse overexpressing galanin under the …