Sepsis is defined as “a life‐threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection.” At present, sepsis continues to …

Despite numerous therapies, cancer remains one of the leading causes of death worldwide
due to the lack of markers for early detection and response to treatment in many patients …

Renal fibrosis is a common pathogenic response to injury in chronic kidney disease (CKD).
The receptor-interacting protein kinase-3 (RIPK3), a regulator of necroptosis, has been …

Sepsis is characterized by organ dysfunction due to a dysregulated immune response to
infection. Currently, no effective treatment for sepsis exists. Platelets are recognized as …

Chronic pain is not only one of the most common health problems, it is often challenging to
treat adequately. Chronic pain has a high prevalence globally, affecting approximately 20 …

Macrophages are now considered to be important players in various inflammatory diseases
as well as tumor progression. Emerging evidence reveals that macrophage metabolic …

Atherosclerosis (AS) is chronic pathological process based on the inflammatory reaction
associated with factors including vascular endothelial dysfunction, inflammation, and …

Inflammasomes are large multimolecular complexes present in the cytosol of stimulated
immune cells; they mediate the activation of caspase-1, leading to cellular pyroptosis. So far …

Although the PINK1-PARK2 pathway contributes to the pathogenesis of Parkinson disease,
its roles in sepsis (a major challenge for critical care) were previously unknown. Here, we …

Objective UCP2 is involved in the maintenance of mitochondrial function, immune response
and regulation of oxidative stress under physiological or pathological conditions. The aim of …