[HTML][HTML] The design of small-molecule prodrugs and activatable phototherapeutics for cancer therapy

HH Han, HM Wang, P Jangili, M Li, L Wu… - Chemical Society …, 2023 - pubs.rsc.org
Cancer remains as one of the most significant health problems, with approximately 19
million people diagnosed worldwide each year. Chemotherapy is a routinely used method to …

[HTML][HTML] Overcoming Cancer Multi-drug Resistance (MDR): Reasons, mechanisms, nanotherapeutic solutions, and challenges

C Duan, M Yu, J Xu, BY Li, Y Zhao… - Biomedicine & …, 2023 - Elsevier
Multi-drug resistance (MDR) in cancer cells, either intrinsic or acquired through various
mechanisms, significantly hinders the therapeutic efficacy of drugs. Typically, the reduced …

[HTML][HTML] CAR-neutrophil mediated delivery of tumor-microenvironment responsive nanodrugs for glioblastoma chemo-immunotherapy

Y Chang, X Cai, R Syahirah, Y Yao, Y Xu, G Jin… - Nature …, 2023 - nature.com
Glioblastoma (GBM) is one of the most aggressive and lethal solid tumors in human. While
efficacious therapeutics, such as emerging chimeric antigen receptor (CAR)-T cells and …

Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides

HR Bridges, JN Blaza, Z Yin, I Chung, MN Pollak… - Science, 2023 - science.org
The molecular mode of action of biguanides, including the drug metformin, which is widely
used in the treatment of diabetes, is incompletely characterized. Here, we define the …

[HTML][HTML] iPSC-derived natural killer cell therapies-expansion and targeting

BH Goldenson, P Hor, DS Kaufman - Frontiers in immunology, 2022 - frontiersin.org
Treatment of cancer with allogeneic natural killer (NK) cell therapies has seen rapid
development, especially use against hematologic malignancies. Clinical trials of NK cell …

Predicting tumour radiosensitivity to deliver precision radiotherapy

JM Price, A Prabhakaran, CML West - Nature Reviews Clinical …, 2023 - nature.com
Owing to advances in radiotherapy, the physical properties of radiation can be optimized to
enable individualized treatment; however, optimization is rarely based on biological …

[HTML][HTML] Dissecting tumor growth: the role of cancer stem cells in drug resistance and recurrence

B Aramini, V Masciale, G Grisendi, F Bertolini, M Maur… - Cancers, 2022 - mdpi.com
Simple Summary Cancer is one of the most debated problems all over the world. Cancer
stem cells are considered responsible of tumor initiation, metastasis, drug resistance, and …

[HTML][HTML] Photooxidation triggered ultralong afterglow in carbon nanodots

GS Zheng, CL Shen, CY Niu, Q Lou, TC Jiang… - Nature …, 2024 - nature.com
It remains a challenge to obtain biocompatible afterglow materials with long emission
wavelengths, durable lifetimes, and good water solubility. Herein we develop a …

Chalcones: Promising therapeutic agents targeting key players and signaling pathways regulating the hallmarks of cancer

AA WalyEldeen, S Sabet, HM El-Shorbagy… - Chemico-Biological …, 2023 - Elsevier
The need for innovative anticancer treatments with high effectiveness and low toxicity is
urgent due to the development of malignancies that are resistant to chemotherapeutic …

[HTML][HTML] Hypoxia in solid tumors: how low oxygenation impacts the “Six Rs” of radiotherapy

A Rakotomalala, A Escande, A Furlan… - Frontiers in …, 2021 - frontiersin.org
Radiotherapy is an important component of cancer treatment, with approximately 50% of all
cancer patients receiving radiation therapy during their course of illness. Nevertheless, solid …