[HTML][HTML] The design of small-molecule prodrugs and activatable phototherapeutics for cancer therapy
Cancer remains as one of the most significant health problems, with approximately 19
million people diagnosed worldwide each year. Chemotherapy is a routinely used method to …
million people diagnosed worldwide each year. Chemotherapy is a routinely used method to …
[HTML][HTML] Overcoming Cancer Multi-drug Resistance (MDR): Reasons, mechanisms, nanotherapeutic solutions, and challenges
C Duan, M Yu, J Xu, BY Li, Y Zhao… - Biomedicine & …, 2023 - Elsevier
Multi-drug resistance (MDR) in cancer cells, either intrinsic or acquired through various
mechanisms, significantly hinders the therapeutic efficacy of drugs. Typically, the reduced …
mechanisms, significantly hinders the therapeutic efficacy of drugs. Typically, the reduced …
[HTML][HTML] CAR-neutrophil mediated delivery of tumor-microenvironment responsive nanodrugs for glioblastoma chemo-immunotherapy
Glioblastoma (GBM) is one of the most aggressive and lethal solid tumors in human. While
efficacious therapeutics, such as emerging chimeric antigen receptor (CAR)-T cells and …
efficacious therapeutics, such as emerging chimeric antigen receptor (CAR)-T cells and …
Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides
The molecular mode of action of biguanides, including the drug metformin, which is widely
used in the treatment of diabetes, is incompletely characterized. Here, we define the …
used in the treatment of diabetes, is incompletely characterized. Here, we define the …
[HTML][HTML] iPSC-derived natural killer cell therapies-expansion and targeting
Treatment of cancer with allogeneic natural killer (NK) cell therapies has seen rapid
development, especially use against hematologic malignancies. Clinical trials of NK cell …
development, especially use against hematologic malignancies. Clinical trials of NK cell …
Predicting tumour radiosensitivity to deliver precision radiotherapy
JM Price, A Prabhakaran, CML West - Nature Reviews Clinical …, 2023 - nature.com
Owing to advances in radiotherapy, the physical properties of radiation can be optimized to
enable individualized treatment; however, optimization is rarely based on biological …
enable individualized treatment; however, optimization is rarely based on biological …
[HTML][HTML] Dissecting tumor growth: the role of cancer stem cells in drug resistance and recurrence
B Aramini, V Masciale, G Grisendi, F Bertolini, M Maur… - Cancers, 2022 - mdpi.com
Simple Summary Cancer is one of the most debated problems all over the world. Cancer
stem cells are considered responsible of tumor initiation, metastasis, drug resistance, and …
stem cells are considered responsible of tumor initiation, metastasis, drug resistance, and …
[HTML][HTML] Photooxidation triggered ultralong afterglow in carbon nanodots
It remains a challenge to obtain biocompatible afterglow materials with long emission
wavelengths, durable lifetimes, and good water solubility. Herein we develop a …
wavelengths, durable lifetimes, and good water solubility. Herein we develop a …
Chalcones: Promising therapeutic agents targeting key players and signaling pathways regulating the hallmarks of cancer
AA WalyEldeen, S Sabet, HM El-Shorbagy… - Chemico-Biological …, 2023 - Elsevier
The need for innovative anticancer treatments with high effectiveness and low toxicity is
urgent due to the development of malignancies that are resistant to chemotherapeutic …
urgent due to the development of malignancies that are resistant to chemotherapeutic …
[HTML][HTML] Hypoxia in solid tumors: how low oxygenation impacts the “Six Rs” of radiotherapy
Radiotherapy is an important component of cancer treatment, with approximately 50% of all
cancer patients receiving radiation therapy during their course of illness. Nevertheless, solid …
cancer patients receiving radiation therapy during their course of illness. Nevertheless, solid …