[HTML][HTML] Nanomechanical mapping of soft materials with the atomic force microscope: methods, theory and applications

R Garcia - Chemical Society Reviews, 2020 - pubs.rsc.org
Fast, high-resolution, non-destructive and quantitative characterization methods are needed
to develop materials with tailored properties at the nanoscale or to understand the …

Atomic force microscopy-based mechanobiology

M Krieg, G Fläschner, D Alsteens, BM Gaub… - Nature Reviews …, 2019 - nature.com
Mechanobiology emerges at the crossroads of medicine, biology, biophysics and
engineering and describes how the responses of proteins, cells, tissues and organs to …

[HTML][HTML] Determination of the elastic moduli of a single cell cultured on a rigid support by force microscopy

PD Garcia, R Garcia - Biophysical journal, 2018 - cell.com
The elastic response of a living cell is affected by its physiological state. This property
provides mechanical fingerprints of a cell's dysfunctionality. The softness (kilopascal range) …

[HTML][HTML] Adhesion and friction in hard and soft contacts: Theory and experiment

VL Popov, Q Li, IA Lyashenko, R Pohrt - Friction, 2021 - Springer
This paper is devoted to an analytical, numerical, and experimental analysis of adhesive
contacts subjected to tangential motion. In particular, it addresses the phenomenon of …

Correlating nuclear morphology and external force with combined atomic force microscopy and light sheet imaging separates roles of chromatin and lamin A/C in …

CM Hobson, M Kern, ET O'Brien III… - Molecular biology of …, 2020 - Am Soc Cell Biol
Nuclei are often under external stress, be it during migration through tight constrictions or
compressive pressure by the actin cap, and the mechanical properties of nuclei govern their …

Recent advances in AFM-based biological characterization and applications at multiple levels

W Liang, H Shi, X Yang, J Wang, W Yang, H Zhang… - Soft Matter, 2020 - pubs.rsc.org
Atomic force microscopy (AFM) has found a wide range of bio-applications in the past few
decades due to its ability to measure biological samples in natural environments at a high …

[HTML][HTML] A survey of physical methods for studying nuclear mechanics and mechanobiology

CM Hobson, MR Falvo, R Superfine - APL bioengineering, 2021 - pubs.aip.org
It is increasingly appreciated that the cell nucleus is not only a home for DNA but also a
complex material that resists physical deformations and dynamically responds to external …

[HTML][HTML] How did correlative atomic force microscopy and super-resolution microscopy evolve in the quest for unravelling enigmas in biology?

A Miranda, AI Gómez-Varela, A Stylianou, LM Hirvonen… - Nanoscale, 2021 - pubs.rsc.org
With the invention of the Atomic Force Microscope (AFM) in 1986 and the subsequent
developments in liquid imaging and cellular imaging it became possible to study the …

[HTML][HTML] Microtubule acetylation is required for mechanosensation in Drosophila

C Yan, F Wang, Y Peng, CR Williams, B Jenkins… - Cell reports, 2018 - cell.com
At the cellular level, α-tubulin acetylation alters the structure of microtubules to render them
mechanically resistant to compressive forces. How this biochemical property of microtubule …

Intracellular mechanics: connecting rheology and mechanotransduction

S Mathieu, JB Manneville - Current opinion in cell biology, 2019 - Elsevier
Cell mechanics is crucial for a wide range of cell functions, including proliferation, polarity,
migration and differentiation. Cells sense external physical cues and translate them into a …