Amyotrophic lateral sclerosis (ALS; motor neuron disease) is a relentlessly progressive
disorder. After half a century of trials, only one drug with modest disease-modifying potency …

In the past two decades, structural and functional neuroimaging findings have greatly
modified longstanding notions regarding the pathophysiology of amyotrophic lateral …

MR-guided focused ultrasound (MRgFUS) is an emerging technology that can accurately
and transiently permeabilize the blood-brain barrier (BBB) for targeted drug delivery to the …

Motor neuron disease can be viewed as an umbrella term describing a heterogeneous
group of conditions, all of which are relentlessly progressive and ultimately fatal. The …

The current study investigated the effects of psychological well-being measured as quality of
life (QoL), depression, current mood and motivation on brain–computer interface (BCI) …

Amyotrophic lateral sclerosis (ALS) is a progressive untreatable neurodegenerative
disorder, leading to the death of the cortical and spinal motoneurons (MNs). Bone marrow …

Amyotrophic lateral sclerosis as a system failure is a concept supported by the finding of
consistent extramotor as well as motor cerebral pathology. The functional correlates of the …

Amyotrophic lateral sclerosis (ALS) encompasses a heterogeneous group of phenotypes
with different progression rates, varying degree of extra-motor involvement and divergent …

Background Gait impairment is poorly characterized in amyotrophic lateral sclerosis (ALS),
despite increasing evidence of extrapyramidal and cerebellar dysfunction. Gait impairment …

Recent evidence has supported the hypothesis that amyotrophic lateral sclerosis (ALS) is a
multi-step disease, as the onset of symptoms occurs after sequential exposure to a defined …