Based on clinical and preclinical evidence, Transient Receptor Potential (TRP) channels
have emerged as potential drug targets for the treatment of osteoarthritis, rheumatoid …

Prolonged or unusual exercise may cause exercise-induced muscle damage (EIMD). To test
whether Zynamite®, a mango leaf extract rich in the natural polyphenol mangiferin …

Transient receptor potential ankyrin 1 (TRPA1) is a nonselective ion channel implicated in
thermosensation and inflammatory pain. It has been reported that expression of the TRPA1 …

Breast carcinoma causes severe pain, which decreases the quality of life of patients. Current
treatments produce adverse effects and have limited efficacy. Transient potential receptor …

Hyperalgesia has become a major problem restricting the clinical application of tooth
bleaching. We hypothesized that transient receptor potential ankyrin 1 (TRPA1), a pain …

Craniofacial muscle pain, such as spontaneous pain and bite-evoked pain, are major
symptoms in patients with temporomandibular disorders and infection. However, the …

The development of novel pain therapeutics hinges on the identification and rigorous
validation of potential targets. Model organisms provide a means to test the involvement of …

Introduction Gout arthritis (GA) is an intermittent inflammatory disease affecting
approximately 10% of the worldwide population. Symptomatic phases (acute flares) are …

Introduction In gout, monosodium urate (MSU) crystals deposit intra-articularly and cause
painful arthritis. In the present study we tested the hypothesis that Transient Receptor Poten …

Hydrogen sulfide (H2S) is a gaseous mediator in various physiological and pathological
processes, including neuroimmune modulation, metabolic pathways, cardiovascular system …