Considerable efforts have been made since the 1950s to better understand the cellular and
molecular mechanisms of action of metformin, a potent antihyperglycaemic agent now …

WNT signalling comprises a diverse spectrum of receptor-mediated pathways activated by a
large family of WNT ligands and influencing fundamental biological processes. WNT …

Objectives: This randomized controlled multicenter trial evaluated coenzyme Q10 (CoQ10)
as adjunctive treatment in chronic heart failure (HF). Background: CoQ10 is an essential …

Cellular reprogramming of somatic cells to patient-specific induced pluripotent stem cells
(iPSCs) enables in vitro modelling of human genetic disorders for pathogenic investigations …

The cardiovascular system plays a key role in sepsis, and septic myocardial depression is a
common finding associated with increased morbidity and mortality. Myocardial depression …

Medical advances and the availability of diagnostic tools have considerably increased life
expectancy and, consequently, the elderly segment of the world population. As age is a …

Reactive oxygen species (ROS) are involved in numerous physiological and
pathophysiological responses. Increasing evidence implicates ROS as signaling molecules …

Of the numerous animal models available for proteomic studies only a small number have
been successfully used in understanding human biology. To date, rodents have been widely …

Cardiovascular disease is the leading cause of death and disability in the Western world. In
order to safeguard the structure and the functionality of the myocardium, it is extremely …

Cardiac dysfunction may complicate the course of severe sepsis and septic shock with
significant implications for patient's survival. The basic pathophysiologic mechanisms …